Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3748997..3749703 Replicon chromosome
Accession NZ_CP048416
Organism Citrobacter freundii strain CitB

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag GZ999_RS17695 Protein ID WP_039556156.1
Coordinates 3748997..3749365 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag GZ999_RS17700 Protein ID WP_039556157.1
Coordinates 3749386..3749703 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ999_RS17680 3744136..3745587 + 1452 WP_003838742.1 Na+/H+ antiporter NhaC -
GZ999_RS17685 3745600..3746781 + 1182 WP_003838744.1 pyridoxal phosphate-dependent aminotransferase -
GZ999_RS17690 3746947..3748425 - 1479 WP_032941279.1 hypothetical protein -
GZ999_RS17695 3748997..3749365 - 369 WP_039556156.1 TA system toxin CbtA family protein Toxin
GZ999_RS17700 3749386..3749703 - 318 WP_039556157.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZ999_RS17705 3749722..3749939 - 218 Protein_3465 DUF987 family protein -
GZ999_RS17710 3749948..3750430 - 483 WP_039556158.1 DNA repair protein RadC -
GZ999_RS17715 3750439..3750882 - 444 WP_096164809.1 antirestriction protein -
GZ999_RS17720 3750913..3751734 - 822 WP_058647033.1 DUF945 domain-containing protein -
GZ999_RS17725 3751854..3752327 - 474 WP_058647034.1 hypothetical protein -
GZ999_RS17730 3752399..3752851 - 453 WP_089586936.1 hypothetical protein -
GZ999_RS17735 3752887..3753603 - 717 WP_058647035.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3739862..3763225 23363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13715.99 Da        Isoelectric Point: 8.7174

>T149409 WP_039556156.1 NZ_CP048416:c3749365-3748997 [Citrobacter freundii]
MKTLPATISRATKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETIIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTATDILQARKACGLMSRCSYREVSNIVLSRSRL

Download         Length: 369 bp

>T149409 NZ_CP064094:c3007871-3007692 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11901.43 Da        Isoelectric Point: 6.6246

>AT149409 WP_039556157.1 NZ_CP048416:c3749703-3749386 [Citrobacter freundii]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTGEMNPRHAHCVILYH
NGFTCEADTLGSCGYVYISVYPTQR

Download         Length: 318 bp

>AT149409 NZ_CP064094:3007546-3007768 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References