Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 759114..759953 Replicon chromosome
Accession NZ_CP048416
Organism Citrobacter freundii strain CitB

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GZ999_RS03635 Protein ID WP_040063377.1
Coordinates 759114..759491 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GZ999_RS03640 Protein ID WP_077249796.1
Coordinates 759540..759953 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ999_RS03615 755153..757012 + 1860 WP_048217170.1 bifunctional glutathionylspermidine amidase/synthase -
GZ999_RS03620 757473..758321 - 849 WP_040229927.1 DUF4942 domain-containing protein -
GZ999_RS03625 758402..758596 - 195 WP_047661001.1 DUF957 domain-containing protein -
GZ999_RS03630 758626..759117 - 492 WP_040063379.1 hypothetical protein -
GZ999_RS03635 759114..759491 - 378 WP_040063377.1 TA system toxin CbtA family protein Toxin
GZ999_RS03640 759540..759953 - 414 WP_077249796.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZ999_RS03645 759922..760143 - 222 WP_038633763.1 DUF987 domain-containing protein -
GZ999_RS03650 760155..760640 - 486 WP_038642868.1 DNA repair protein RadC -
GZ999_RS03655 760693..761169 - 477 WP_047661000.1 antirestriction protein -
GZ999_RS03660 761166..761429 - 264 WP_038633754.1 hypothetical protein -
GZ999_RS03665 761429..762247 - 819 WP_001234374.1 DUF945 domain-containing protein -
GZ999_RS03670 762363..762613 - 251 Protein_720 DUF905 family protein -
GZ999_RS03675 762804..763271 - 468 WP_000727137.1 hypothetical protein -
GZ999_RS03680 763368..763769 - 402 WP_047660999.1 hypothetical protein -
GZ999_RS03685 763975..764862 - 888 WP_047661008.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(33-132)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14020.87 Da        Isoelectric Point: 6.8604

>T149397 WP_040063377.1 NZ_CP048416:c759491-759114 [Citrobacter freundii]
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRAVTDITTGKYSKMTR

Download         Length: 378 bp

>T149397 NZ_CP064092:c480131-479385 [Bacillus licheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTTATTGTTTTGGCGCTGGCTCTGTACGTAGCTGCCGTGTGGCGTTTTGA
AAAACAGCTCGCCGAAAAAACGGTCGCCATCAGAAAAACGTGGTACCTTCTTTATGTCATCGGCGCCGTGATATATTGGA
CGCACGATCCGCAGTCAATTTTCACAAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGTTGACAGACGCTTTT
ATTTTCTTAAATGCCTACTTTAAAAAGCTCGGCAGCTCTGAACTCGCGACAGATACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACGTATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGCATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
CCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGATTATCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15178.32 Da        Isoelectric Point: 7.7885

>AT149397 WP_077249796.1 NZ_CP048416:c759953-759540 [Citrobacter freundii]
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIAIYPTPSVTS

Download         Length: 414 bp

>AT149397 NZ_CP064092:c479385-479212 [Bacillus licheniformis]
ATGGAGCCTGCTTTTCAGCAAGACCAGGAAAGCGTAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAGGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References