Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2857861..2858324 Replicon chromosome
Accession NZ_CP048415
Organism Algoriphagus sp. NBT04N3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GYM62_RS12365 Protein ID WP_219956627.1
Coordinates 2858082..2858324 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GYM62_RS12360 Protein ID WP_255590373.1
Coordinates 2857861..2858085 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYM62_RS12345 (GYM62_12335) 2855029..2855259 - 231 WP_219956630.1 hypothetical protein -
GYM62_RS12350 (GYM62_12340) 2855406..2855810 + 405 WP_255590693.1 helix-turn-helix transcriptional regulator -
GYM62_RS12355 (GYM62_12345) 2855969..2856826 - 858 WP_219956631.1 RHS repeat-associated core domain-containing protein -
GYM62_RS12360 (GYM62_12350) 2857861..2858085 - 225 WP_255590373.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GYM62_RS12365 (GYM62_12355) 2858082..2858324 - 243 WP_219956627.1 type II toxin-antitoxin system HicA family toxin Toxin
GYM62_RS12370 (GYM62_12360) 2858372..2859247 - 876 WP_219956632.1 tyrosine-type recombinase/integrase -
GYM62_RS12375 (GYM62_12365) 2859241..2860152 - 912 WP_219956628.1 tyrosine-type recombinase/integrase -
GYM62_RS12380 (GYM62_12370) 2860332..2860673 - 342 WP_219956633.1 hypothetical protein -
GYM62_RS12385 (GYM62_12375) 2860570..2863134 - 2565 WP_219956634.1 CHC2 zinc finger domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2824641..2863858 39217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9260.93 Da        Isoelectric Point: 10.0335

>T149394 WP_219956627.1 NZ_CP048415:c2858324-2858082 [Algoriphagus sp. NBT04N3]
MSKKEKLIARFLGMPSDFHYDEMVKLLGYFGFEEVKKGKTSGSRVKFENGEGVPVMLHKPHPSGIMKQYQMKQVRELLEL

Download         Length: 243 bp

>T149394 NZ_CP064090:c354653-354303 [Brevibacillus parabrevis]
GTGATTGTCAAACGTGGCGATGTGTTTTTCGCGGACCTGTCACCGGTCGTTGGCTCTGAGCAAGGAGGCGTGCGGCCTGT
TTTAGTCATTCAGAACGACATTGGAAATCGATTTAGTCCGACGGTCATCGTCGCAGCCATTACGGCGCAAATTCAGAAGG
CAAAGCTGCCTACGCATGTGGAAATTGACGCAAAAACATATGGATTTGATCGTGACTCCGTCATTTTGTTGGAACAAATA
CGAACCATTGACAAACAAAGGCTGACCGATAAGATTACCCATCTCGATGACGAGATGATGGATCGGGTCAATGAGTCTTT
ACAAATCAGCTTGGGCCTCATTGATTTCTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8318.34 Da        Isoelectric Point: 4.6258

>AT149394 WP_255590373.1 NZ_CP048415:c2858085-2857861 [Algoriphagus sp. NBT04N3]
MKYLEYKGYTGSIEYSPQDSLLYGKVLGIRGLISYEGETGKHLEEDFREAVDAYLADCKEEGKSPEKPFKGASM

Download         Length: 225 bp

>AT149394 NZ_CP064090:c354956-354657 [Brevibacillus parabrevis]
ATGGTTGGAGGTGGATTTGTCTTGTCGAAGTCAAACACGAAACGCATCATGATCAGTTTGCCGCAACACTTGCTACAGGA
AGTGGATGGCGTCATTCAAAAGGAGAAATCCAATCGCAGCGAGTTTATTCGTCAGGCGATGCATTTGTATTTGAAGGAGC
GTAAAAAACGTACGATCCGGGAGACAATGCAAAAAGGGTATATGGAGATGGCGAAGATTAATCTGAAAATGGCATCGGAG
GCTTTTGGCGCTGAGGAAGAGGCTGACCATACTCTTGTCCGCTTAGTTAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References