Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2849637..2850217 Replicon chromosome
Accession NZ_CP048415
Organism Algoriphagus sp. NBT04N3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GYM62_RS12325 Protein ID WP_219956627.1
Coordinates 2849975..2850217 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GYM62_RS12320 Protein ID WP_219956626.1
Coordinates 2849637..2849978 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYM62_RS12295 (GYM62_12285) 2845028..2846098 - 1071 WP_219956623.1 toprim domain-containing protein -
GYM62_RS12300 2846231..2846821 - 591 WP_219956624.1 CHC2 zinc finger domain-containing protein -
GYM62_RS12305 (GYM62_12295) 2846961..2847344 + 384 WP_255590371.1 helix-turn-helix transcriptional regulator -
GYM62_RS12310 (GYM62_12300) 2847368..2847820 - 453 WP_219956616.1 hypothetical protein -
GYM62_RS12315 (GYM62_12305) 2847823..2848713 - 891 WP_219956625.1 RHS repeat-associated core domain-containing protein -
GYM62_RS12320 (GYM62_12310) 2849637..2849978 - 342 WP_219956626.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GYM62_RS12325 (GYM62_12315) 2849975..2850217 - 243 WP_219956627.1 type II toxin-antitoxin system HicA family toxin Toxin
GYM62_RS12330 (GYM62_12320) 2850378..2851139 - 762 WP_255590372.1 tyrosine-type recombinase/integrase -
GYM62_RS12335 (GYM62_12325) 2851133..2852044 - 912 WP_219956628.1 tyrosine-type recombinase/integrase -
GYM62_RS12340 (GYM62_12330) 2852223..2855024 - 2802 WP_219956629.1 CHC2 zinc finger domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2824641..2863858 39217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9260.93 Da        Isoelectric Point: 10.0335

>T149393 WP_219956627.1 NZ_CP048415:c2850217-2849975 [Algoriphagus sp. NBT04N3]
MSKKEKLIARFLGMPSDFHYDEMVKLLGYFGFEEVKKGKTSGSRVKFENGEGVPVMLHKPHPSGIMKQYQMKQVRELLEL

Download         Length: 243 bp

>T149393 NZ_CP064089:859108-859458 [Bacillus altitudinis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAAATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12698.38 Da        Isoelectric Point: 5.7775

>AT149393 WP_219956626.1 NZ_CP048415:c2849978-2849637 [Algoriphagus sp. NBT04N3]
MKYLEYKGYTGSIEYSPQDSLLYGKVLGIRGLISYEGETGKHLEEDFREAVDAYLADCKEEGKSPEKPFKGSFNVRISAT
LHQRAALLAMEAKTSLNNFVAEAIRFRVDKEPA

Download         Length: 342 bp

>AT149393 NZ_CP064089:858822-859103 [Bacillus altitudinis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References