Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1898998..1899578 Replicon chromosome
Accession NZ_CP048415
Organism Algoriphagus sp. NBT04N3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GYM62_RS08285 Protein ID WP_219959066.1
Coordinates 1899336..1899578 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GYM62_RS08280 Protein ID WP_219959065.1
Coordinates 1898998..1899339 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYM62_RS08255 (GYM62_08245) 1895086..1895790 + 705 WP_219959061.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
GYM62_RS08260 (GYM62_08250) 1895878..1896231 + 354 WP_219959062.1 MerR family transcriptional regulator -
GYM62_RS08265 (GYM62_08255) 1896203..1897330 + 1128 WP_219959063.1 DNA-processing protein DprA -
GYM62_RS08270 (GYM62_08260) 1897333..1897884 - 552 WP_219959064.1 PepSY domain-containing protein -
GYM62_RS08275 (GYM62_08265) 1897888..1898739 - 852 WP_091650139.1 hydroxymethylglutaryl-CoA lyase -
GYM62_RS08280 (GYM62_08270) 1898998..1899339 - 342 WP_219959065.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GYM62_RS08285 (GYM62_08275) 1899336..1899578 - 243 WP_219959066.1 type II toxin-antitoxin system HicA family toxin Toxin
GYM62_RS08290 (GYM62_08280) 1899754..1900488 - 735 WP_219959067.1 energy transducer TonB -
GYM62_RS08295 (GYM62_08285) 1900563..1901516 - 954 WP_219959068.1 methylenetetrahydrofolate reductase [NAD(P)H] -
GYM62_RS08300 (GYM62_08290) 1901513..1904230 - 2718 WP_219959069.1 methionine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9189.89 Da        Isoelectric Point: 10.3391

>T149391 WP_219959066.1 NZ_CP048415:c1899578-1899336 [Algoriphagus sp. NBT04N3]
MSKKEKLIARFLGMPSDFHYNEMVKLLGYFGFSEVKKGKTSGSRVKFENEGGAPIMLHKPHPSGIMKQYQMKQIKELLEL

Download         Length: 243 bp

>T149391 NZ_CP064062:c1898961-1898560 [Brucella anthropi]
ATGCTGAAGTACATGCTGGATACAAATATATGCATTTTCACGATCAAGAACCGGCCGCAGCAAGTGCGCGAGGCGTTCAA
CCGCTTCCACGATCAATTGTGCATCAGCTCAGTCAGTTTAATGGAGCTGATTTACGGGGCGGAGAAGTCTGCCCATCCTG
AAAAGAACCTTGCAGTCGTGGAAGGGTTCGCAGCTCGCCTTGAGGTGTTATCGTATGATGAACCGGCAGCAAACCATACG
GGCCAATTACGTGCTGAATTGGCCCGCAGTGGAACTCCAATCGGTCCATACGATCAATTGATTGCTGGCCATGCTCGCTC
GCGTGGCCTGATAATCGTTACAAACAATCGCAGGGAATTTGATCGTGTTCCTGGCTTGCGAGTAGAAGACTGGACTGATT
AA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12703.57 Da        Isoelectric Point: 8.0068

>AT149391 WP_219959065.1 NZ_CP048415:c1899339-1898998 [Algoriphagus sp. NBT04N3]
MKYLEYKGYTGSIEYSPQDSLLYGKVLGIKGLISYEGETGKHLEEDFKEAVDTYLAHCKEKGISPEKPFKGSFNVRIPAK
LHQKAALLAMEAKTSLNNFVAEAIRYRVEKDPA

Download         Length: 342 bp

>AT149391 NZ_CP064062:c1899191-1898961 [Brucella anthropi]
ATGGAGCAGGGAGCAGTATTCCAGAGCAACCGGAGCCAAGCTATCCGCTTGCCAAAAGCAGTAGCATTGCCTGCTGATGT
GAAACGCGTTGATATTGTTGCTGTGGGGCGCACTCGAATCATAGCACCCGCTGGTGAGGTCTGGGATAGCTGGTTTGATA
GCTTAGAGGCGACTTCCGACTTCATGAATGAGCGTGATCAGCCTGCTCCACAGGAACGCGAGGCGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References