Detailed information of TA system TA149390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1009240..1010870
• Replicon: chromosome
• Accession: NZ_CP048415
• Organism: Algoriphagus sp. NBT04N3

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: GYM62_RS04340
• Protein ID: WP_219958467.1
• Coordinates: 1009569..1010870 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: GYM62_RS04335
• Protein ID: WP_219958466.1
• Coordinates: 1009240..1009575 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYM62_RS04335 (GYM62_04335)	1009240..1009575	+	336	WP_219958466.1	helix-turn-helix transcriptional regulator	Antitoxin
GYM62_RS04340 (GYM62_04340)	1009569..1010870	+	1302	WP_219958467.1	type II toxin-antitoxin system HipA family toxin	Toxin
GYM62_RS04345 (GYM62_04345)	1010909..1012030	-	1122	WP_219958468.1	ATP-binding protein	-
GYM62_RS04350 (GYM62_04350)	1012122..1012892	-	771	WP_219958469.1	YdcF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-66)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 49079.13 Da
• Isoelectric Point: 7.3887

>T149390 WP_219958467.1 NZ_CP048415:1009569-1010870 [Algoriphagus sp. NBT04N3]
MVNAAEIWLWNKLVGAVLWDESRQLANFEFDRNFLRSGWDISPILMPLSQGKRLYSFPETRRSRDDAFDTFKGLPGLLAD
MLPDKYGNQLINAWLVQNGRPSDSLNPVELLCFIGKRGVGALEIKPALRTETGRASSLELESLVGIAQKVLNSKENFQTD
LSLEEEEALADILKIGTSAGGARAKAVIAFNPKTGEVKSGQVKAPKGFSHWIIKFDGVHDSQFGATVGYGRVEMAYYLMA
KEAGIEMNECRLLEENGRAHFMTKRFDRTDSGEKIHMQSLCGIRHFDFNQVGVYSYEQVFETMRMLRLTYPEAEQQFVRM
VFNVLARNCDDHTKNFAFLMDQSGKWALSPAYDICHAYRPGSIWVSRQSLQVNGKREGITDSDFLEVAKKMNIKRPQEKI
ERVKQAVKRWGEFAEEAKVEPILRDSIQGTLLV

Nucleotide

• Length: 1302 bp

>T149390 NZ_CP064062:1869803-1870180 [Brucella anthropi]
GTGATACTAGCAGATACTTCCATTTGGATTGATCATTTCCGCCGAGGTGATAACGATCTTGTAAAAATTATTGGTAACGA
TCTTCTGCTTTGCCATCCGGCAGTTATTGGCGAACTTGCTTTGGGCAGCCTACGCGACAGGACCGCTGTGTTAACTTTTC
TCCGCGCACAGCGTGAGACTATCGTAGCAACCCACGACGAGGTTATGACTCTCATTGAGAGGCATAGCGTTTTTAGCATG
GGTATTGGCTACACGGATGCTCACTTGCTCGCTTCTGTCCTACTTGATCAGCGCACATCCCTTTGGACTCGAGACAAGCG
GCTCAAGCTAGCGGCCCTCAAAGCTGGCGCTGCTCTTTATGAGCCCTTTCACAGTTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12859.80 Da
• Isoelectric Point: 5.2300

>AT149390 WP_219958466.1 NZ_CP048415:1009240-1009575 [Algoriphagus sp. NBT04N3]
MNISQLSDAAILQMIGEFIKKKRMDLNKTQDTLSYEAGISRSTLSLLERGEKVNLITLIQVLRVLDELQILEVFETQTQI
SPLEYIKLQKKQERQRVRNTDQAAENPPSEW

Nucleotide

• Length: 336 bp

>AT149390 NZ_CP064062:1869606-1869806 [Brucella anthropi]
ATGCGTTCAACCATTAATCTTGATGATAATCTCTTGGAAAAAGCCAGATCCCTGACGGGCACAAAGGAGACAGCCGCTTT
GGTCCGCCAAGCGTTAGAAGCACTCGTGCGCGTCGAGACTGGTAAACGGCTTATCGCTCTTGGAGGTACCATGCCGGACG
CTGAAGCCGCCCCCCGCCGTCGGAGCTCAGTGAATAAGTGA