Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 5478873..5479378 Replicon chromosome
Accession NZ_CP048408
Organism Pseudomonas fluorescens strain DR397

Toxin (Protein)


Gene name relE Uniprot ID Q3K782
Locus tag GZH78_RS24495 Protein ID WP_011335833.1
Coordinates 5479124..5479378 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0C2A0X2
Locus tag GZH78_RS24490 Protein ID WP_039765667.1
Coordinates 5478873..5479127 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH78_RS24470 5474954..5475283 + 330 WP_074691023.1 hypothetical protein -
GZH78_RS24475 5475439..5475810 + 372 WP_085610938.1 hypothetical protein -
GZH78_RS24480 5475930..5476676 + 747 WP_163976400.1 hypothetical protein -
GZH78_RS24485 5476748..5478673 + 1926 WP_163976402.1 alkaline phosphatase family protein -
GZH78_RS24490 5478873..5479127 + 255 WP_039765667.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GZH78_RS24495 5479124..5479378 + 255 WP_011335833.1 Txe/YoeB family addiction module toxin Toxin
GZH78_RS24500 5479387..5480559 - 1173 WP_085668161.1 aspartate aminotransferase family protein -
GZH78_RS24505 5480662..5481567 + 906 WP_039765662.1 LysR family transcriptional regulator -
GZH78_RS24510 5481611..5482015 + 405 WP_163976404.1 GNAT family N-acetyltransferase -
GZH78_RS24515 5482079..5482603 + 525 WP_074691017.1 hypothetical protein -
GZH78_RS24520 5482777..5483481 + 705 WP_039765656.1 hypothetical protein -
GZH78_RS24525 5483551..5484042 - 492 WP_163976406.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9950.59 Da        Isoelectric Point: 9.6300

>T149384 WP_011335833.1 NZ_CP048408:5479124-5479378 [Pseudomonas fluorescens]
MKIQFTPTGWEDYLWFQQNDKAGLKRINLLIKAIQRQPFEGLGKPEPLKHNMSGFWSRRITAEHRLVYAIVDGEICVITC
RFHY

Download         Length: 255 bp

>T149384 NZ_CP064055:c1048825-1048622 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCAATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.87 Da        Isoelectric Point: 5.1314

>AT149384 WP_039765667.1 NZ_CP048408:5478873-5479127 [Pseudomonas fluorescens]
MDTINYTTARAHLAETMDRVNEDCAPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSPANAERLIKSIGEMRAGKAKVRQ
LIEE

Download         Length: 255 bp

>AT149384 NZ_CP064055:c1049248-1048889 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q3K782

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2A0X2

References