Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1952804..1953315 Replicon chromosome
Accession NZ_CP048405
Organism Streptacidiphilus sp. PB12-B1b

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GXW83_RS08860 Protein ID WP_182442533.1
Coordinates 1952804..1953061 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GXW83_RS08865 Protein ID WP_182442534.1
Coordinates 1953058..1953315 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXW83_RS08835 1948162..1949088 - 927 WP_182442529.1 phytanoyl-CoA dioxygenase family protein -
GXW83_RS08840 1949326..1950408 - 1083 WP_182442530.1 CU044_5270 family protein -
GXW83_RS08845 1950405..1951025 - 621 WP_182442531.1 RNA polymerase sigma factor -
GXW83_RS08850 1951133..1951315 - 183 WP_182447175.1 hypothetical protein -
GXW83_RS08855 1952336..1952773 + 438 WP_182442532.1 DNA-binding protein -
GXW83_RS08860 1952804..1953061 - 258 WP_182442533.1 Txe/YoeB family addiction module toxin Toxin
GXW83_RS08865 1953058..1953315 - 258 WP_182442534.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GXW83_RS08870 1953517..1954932 - 1416 WP_182442535.1 type I glutamate--ammonia ligase -
GXW83_RS08875 1955299..1955769 + 471 WP_182442536.1 RDD family protein -
GXW83_RS08880 1956033..1956725 - 693 WP_182442537.1 DUF4191 domain-containing protein -
GXW83_RS08885 1956832..1957023 - 192 WP_182442538.1 hypothetical protein -
GXW83_RS08890 1957207..1958156 - 950 Protein_1736 lipoyl synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10065.42 Da        Isoelectric Point: 8.9196

>T149375 WP_182442533.1 NZ_CP048405:c1953061-1952804 [Streptacidiphilus sp. PB12-B1b]
VKIVFASRAWEDYLWWQLQDRKTLKRINALIADIASNGNEGIGKPEPLKHGFQGYWSRRINDEHRLIYKATDDTVLIAQC
RYHHE

Download         Length: 258 bp

>T149375 NZ_CP064049:185059-185325 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9501.53 Da        Isoelectric Point: 4.3135

>AT149375 WP_182442534.1 NZ_CP048405:c1953315-1953058 [Streptacidiphilus sp. PB12-B1b]
MKTMTYSESRARYAEVLNSVNDDREEVVITRAGHDPVVIVSLEDYESLKETAYLLRSPANARRLLASIDELENGGGTVRE
LATDE

Download         Length: 258 bp

>AT149375 NZ_CP064049:184796-185059 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References