Detailed information of TA system TA149371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3044485..3045506
• Replicon: chromosome
• Accession: NZ_CP048404
• Organism: Proteus mirabilis strain N18-00201

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: GYM49_RS14085
• Protein ID: WP_143474977.1
• Coordinates: 3044937..3045506 (+)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: GYM49_RS14080
• Protein ID: WP_163806848.1
• Coordinates: 3044485..3044937 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYM49_RS14060	3040271..3040801	-	531	WP_004245524.1	RNA pyrophosphohydrolase	-
GYM49_RS14065	3041070..3042083	+	1014	WP_135003258.1	thiamine ABC transporter substrate binding subunit	-
GYM49_RS14070	3042083..3043663	+	1581	WP_004245526.1	thiamine/thiamine pyrophosphate ABC transporter permease ThiP	-
GYM49_RS14075	3043656..3044357	+	702	WP_004245527.1	thiamine ABC transporter ATP-binding protein ThiQ	-
GYM49_RS14080	3044485..3044937	+	453	WP_163806848.1	helix-turn-helix domain-containing protein	Antitoxin
GYM49_RS14085	3044937..3045506	+	570	WP_143474977.1	PIN domain-containing protein	Toxin
GYM49_RS14090	3045622..3047976	+	2355	WP_143474976.1	DNA polymerase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-113)

Antitoxin

• Helix-turn-helix domain, group 17 (80-127)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21618.11 Da
• Isoelectric Point: 7.3470

>T149371 WP_143474977.1 NZ_CP048404:3044937-3045506 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYES
LICGLKLPDPNDRHVLVAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Nucleotide

• Length: 570 bp

>T149371 NZ_CP064046:4533991-4534272 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16714.18 Da
• Isoelectric Point: 5.7723

>AT149371 WP_163806848.1 NZ_CP048404:3044485-3044937 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSLIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIIAYKNELEQKRLDALAELSQLDQEMDMGY

Nucleotide

• Length: 453 bp

>AT149371 NZ_CP064046:4533759-4534001 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGAGGTTAAGGTGAGTCTGGATGACCTA
TGA