Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 108336..109072 | Replicon | plasmid pKPS01_p1 |
| Accession | NZ_CP048390 | ||
| Organism | Klebsiella pneumoniae strain S01 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A2J5Q928 |
| Locus tag | GZH33_RS26105 | Protein ID | WP_004098919.1 |
| Coordinates | 108336..108818 (-) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | GZH33_RS26110 | Protein ID | WP_032415032.1 |
| Coordinates | 108806..109072 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GZH33_RS26075 (GZH33_26530) | 103383..104348 | + | 966 | WP_004118146.1 | DMT family transporter | - |
| GZH33_RS26080 | 104416..104535 | - | 120 | Protein_108 | transcriptional regulator | - |
| GZH33_RS26085 (GZH33_26535) | 104548..105051 | - | 504 | Protein_109 | CSS-motif domain-containing protein | - |
| GZH33_RS26090 (GZH33_26540) | 105530..105787 | + | 258 | WP_152309088.1 | hypothetical protein | - |
| GZH33_RS26095 (GZH33_26545) | 106071..106703 | + | 633 | WP_001567369.1 | hypothetical protein | - |
| GZH33_RS26100 (GZH33_26550) | 106732..108135 | - | 1404 | WP_001567368.1 | ISNCY-like element ISKpn21 family transposase | - |
| GZH33_RS26105 (GZH33_26555) | 108336..108818 | - | 483 | WP_004098919.1 | GNAT family N-acetyltransferase | Toxin |
| GZH33_RS26110 (GZH33_26560) | 108806..109072 | - | 267 | WP_032415032.1 | DUF1778 domain-containing protein | Antitoxin |
| GZH33_RS26115 (GZH33_26565) | 109248..109502 | - | 255 | WP_016528790.1 | hypothetical protein | - |
| GZH33_RS26120 (GZH33_26570) | 109578..109835 | - | 258 | WP_004098928.1 | hypothetical protein | - |
| GZH33_RS26125 (GZH33_26575) | 109884..110087 | - | 204 | WP_004150739.1 | HHA domain-containing protein | - |
| GZH33_RS26130 (GZH33_26580) | 110148..110642 | - | 495 | WP_250354566.1 | DNA-binding protein | - |
| GZH33_RS26135 (GZH33_26585) | 110673..111239 | - | 567 | WP_250354567.1 | hypothetical protein | - |
| GZH33_RS26140 (GZH33_26590) | 111236..111499 | - | 264 | WP_250354568.1 | hypothetical protein | - |
| GZH33_RS26145 (GZH33_26595) | 111813..111992 | + | 180 | WP_004118349.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| GZH33_RS26150 (GZH33_26600) | 112047..113585 | - | 1539 | WP_004201219.1 | IS66-like element ISKpn24 family transposase | - |
| GZH33_RS26155 (GZH33_26605) | 113634..113981 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(A) / ant(3'')-Ia / aph(3')-Ia / mph(A) | - | 1..205754 | 205754 | |
| - | inside | IScluster/Tn | - | - | 106732..114615 | 7883 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17335.06 Da Isoelectric Point: 10.0704
>T149366 WP_004098919.1 NZ_CP048390:c108818-108336 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
Download Length: 483 bp
>T149366 NZ_CP064044:c5248914-5248696 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10123.53 Da Isoelectric Point: 4.5141
>AT149366 WP_032415032.1 NZ_CP048390:c109072-108806 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV
Download Length: 267 bp
>AT149366 NZ_CP064044:c5249315-5248941 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|