Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4035906..4036525 | Replicon | chromosome |
Accession | NZ_CP048389 | ||
Organism | Klebsiella pneumoniae strain S01 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | GZH33_RS19545 | Protein ID | WP_002892050.1 |
Coordinates | 4036307..4036525 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | GZH33_RS19540 | Protein ID | WP_002892066.1 |
Coordinates | 4035906..4036280 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GZH33_RS19530 (4031058) | 4031058..4032251 | + | 1194 | WP_002892072.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
GZH33_RS19535 (4032274) | 4032274..4035420 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
GZH33_RS19540 (4035906) | 4035906..4036280 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
GZH33_RS19545 (4036307) | 4036307..4036525 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
GZH33_RS19550 (4036684) | 4036684..4037250 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
GZH33_RS19555 (4037222) | 4037222..4037362 | - | 141 | WP_004147370.1 | hypothetical protein | - |
GZH33_RS19560 (4037383) | 4037383..4037853 | + | 471 | WP_002892026.1 | YlaC family protein | - |
GZH33_RS19565 (4037828) | 4037828..4039279 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
GZH33_RS19570 (4039380) | 4039380..4040078 | + | 699 | WP_002892021.1 | GNAT family protein | - |
GZH33_RS19575 (4040075) | 4040075..4040215 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
GZH33_RS19580 (4040215) | 4040215..4040478 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T149360 WP_002892050.1 NZ_CP048389:4036307-4036525 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T149360 NZ_CP064037:2179153-2179431 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAATCGCTAAATGATCGTGAAAAGATCTTTGAGTTTCTTTATGACTTCAACCCTGACGCGGC
AGATAAAACTGACGAAATCATCGAAACTAAAGTAGAGAATTTACTTGAGCAACCACTGATGGGTGTTCAACGAGATGGTA
TTCGAGGGCGACTACTAATTATCCCCGAAATCTCGATGATTGTTTCCTACTGGGTTGACGGCTCAGTAATTCGTATAATG
CGAGTTCTACACCAGAAGCAGAAATTCCCTACCGACTGA
ATGATTTTATGGGAAGAAGAATCGCTAAATGATCGTGAAAAGATCTTTGAGTTTCTTTATGACTTCAACCCTGACGCGGC
AGATAAAACTGACGAAATCATCGAAACTAAAGTAGAGAATTTACTTGAGCAACCACTGATGGGTGTTCAACGAGATGGTA
TTCGAGGGCGACTACTAATTATCCCCGAAATCTCGATGATTGTTTCCTACTGGGTTGACGGCTCAGTAATTCGTATAATG
CGAGTTCTACACCAGAAGCAGAAATTCCCTACCGACTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT149360 WP_002892066.1 NZ_CP048389:4035906-4036280 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT149360 NZ_CP064037:2178872-2179156 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGACGAAGTTAAACGCTTAGCTCAACAAATGGCAGAGAGCCAAGGACGCAC
ACTTAGCGATGCTTGCCGTGAGCTTACCGAGCAAATGGCTGAACAACAACGAAAAGCATTATCTCACGACAATTGGTTGA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAAGCTTCATTTGTTGATCACGACTCAGCAAAAGCACGA
ATGGCTGAGCGAAAAGCTAAGATTCGAAACCGAGGTCAACAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGACGAAGTTAAACGCTTAGCTCAACAAATGGCAGAGAGCCAAGGACGCAC
ACTTAGCGATGCTTGCCGTGAGCTTACCGAGCAAATGGCTGAACAACAACGAAAAGCATTATCTCACGACAATTGGTTGA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAAGCTTCATTTGTTGATCACGACTCAGCAAAAGCACGA
ATGGCTGAGCGAAAAGCTAAGATTCGAAACCGAGGTCAACAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |