Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839930..840587 Replicon chromosome
Accession NZ_CP048389
Organism Klebsiella pneumoniae strain S01

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GZH33_RS04145 Protein ID WP_002916310.1
Coordinates 840177..840587 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GZH33_RS04140 Protein ID WP_002916312.1
Coordinates 839930..840196 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH33_RS04115 (835086) 835086..836519 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
GZH33_RS04120 (836638) 836638..837366 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GZH33_RS04125 (837416) 837416..837727 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GZH33_RS04130 (837891) 837891..838550 + 660 WP_002916317.1 hemolysin III family protein -
GZH33_RS04135 (838701) 838701..839684 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
GZH33_RS04140 (839930) 839930..840196 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GZH33_RS04145 (840177) 840177..840587 + 411 WP_002916310.1 protein YgfX Toxin
GZH33_RS04150 (840594) 840594..841115 - 522 WP_004144730.1 flavodoxin FldB -
GZH33_RS04155 (841216) 841216..842112 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GZH33_RS04160 (842135) 842135..842848 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GZH33_RS04165 (842854) 842854..844587 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T149349 WP_002916310.1 NZ_CP048389:840177-840587 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T149349 NZ_CP064030:36652-36954 [Dyella caseinilytica]
ATGGCAGCAAAAAAGAAAGAAGTTTTCAGCCGATACGACACCGCGGATTACCTCAACAGCGAAGAAGACATTGCTGCCTA
TCTGGAGGCGTGTTCGGAAGAGAATGATCCCGCGCTAATGGCTGCAGCGTTAGGTGCCGTCGCACGCGCCCGAAACATGA
GCCAGCTTGCGCGCGATACAGGCCTTACCCGCGAAGGTCTCTACAAAGCATTATCCGTCGATGGCAACCCAAGCCTGGCG
ACCGCCATGAGGGTGGCCAATGCACTCGGTTATCAATTGAGATTGGTGCCACTCGCACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT149349 WP_002916312.1 NZ_CP048389:839930-840196 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT149349 NZ_CP064030:36356-36649 [Dyella caseinilytica]
ATGGAGATTGTCAAGAGCAGGATGTTCGACCGATGGTTGCGTGGACTCAACGATCGGCAGGCAAAGGCTCGGATTCAGAT
GCGAATTGACCGCTTGAATCTGGGGAATCCCGGCCAACACCGGAATCTGACCGGCGGTATCCGGGAGATGAAAATCGACT
ACGGGCCGGGCTACAGGGTCTATTACACCATCCGTGGTGCTGTGTTGATCATTTTGCTTTGCGGTGGAGATAAGACCACG
CAACAGCAGGACATCGACAATGCCATCCGTTTGGCAGATGCCTGGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References