Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 693293..693972 Replicon chromosome
Accession NZ_CP048389
Organism Klebsiella pneumoniae strain S01

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag GZH33_RS03400 Protein ID WP_020324801.1
Coordinates 693631..693972 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag GZH33_RS03395 Protein ID WP_020324792.1
Coordinates 693293..693610 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH33_RS03370 (688507) 688507..691659 + 3153 WP_022631414.1 AIDA repeat-containing protein -
GZH33_RS03375 (691752) 691752..691991 + 240 WP_020324820.1 DUF905 domain-containing protein -
GZH33_RS03380 (692094) 692094..692552 + 459 WP_020324813.1 antirestriction protein -
GZH33_RS03385 (692568) 692568..693044 + 477 WP_020324797.1 RadC family protein -
GZH33_RS03390 (693053) 693053..693280 + 228 WP_020324796.1 DUF987 domain-containing protein -
GZH33_RS03395 (693293) 693293..693610 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZH33_RS03400 (693631) 693631..693972 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
GZH33_RS03405 (694088) 694088..694921 + 834 WP_020324805.1 DUF4942 domain-containing protein -
GZH33_RS03415 (695224) 695224..695730 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
GZH33_RS03420 (695830) 695830..697671 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / fimI / fimC / fimD / fimD / fimF / fimG 646507..694921 48414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T149348 WP_020324801.1 NZ_CP048389:693631-693972 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T149348 NZ_CP064030:36356-36649 [Dyella caseinilytica]
ATGGAGATTGTCAAGAGCAGGATGTTCGACCGATGGTTGCGTGGACTCAACGATCGGCAGGCAAAGGCTCGGATTCAGAT
GCGAATTGACCGCTTGAATCTGGGGAATCCCGGCCAACACCGGAATCTGACCGGCGGTATCCGGGAGATGAAAATCGACT
ACGGGCCGGGCTACAGGGTCTATTACACCATCCGTGGTGCTGTGTTGATCATTTTGCTTTGCGGTGGAGATAAGACCACG
CAACAGCAGGACATCGACAATGCCATCCGTTTGGCAGATGCCTGGGAGGATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT149348 WP_020324792.1 NZ_CP048389:693293-693610 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT149348 NZ_CP064030:36652-36954 [Dyella caseinilytica]
ATGGCAGCAAAAAAGAAAGAAGTTTTCAGCCGATACGACACCGCGGATTACCTCAACAGCGAAGAAGACATTGCTGCCTA
TCTGGAGGCGTGTTCGGAAGAGAATGATCCCGCGCTAATGGCTGCAGCGTTAGGTGCCGTCGCACGCGCCCGAAACATGA
GCCAGCTTGCGCGCGATACAGGCCTTACCCGCGAAGGTCTCTACAAAGCATTATCCGTCGATGGCAACCCAAGCCTGGCG
ACCGCCATGAGGGTGGCCAATGCACTCGGTTATCAATTGAGATTGGTGCCACTCGCACACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References