149344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4492240..4492828 Replicon chromosome
Accession NZ_CP048388
Organism Citrobacter portucalensis strain PNUCL1

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B0T4T9
Locus tag GZH81_RS21115 Protein ID WP_032942059.1
Coordinates 4492240..4492557 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag GZH81_RS21120 Protein ID WP_032942057.1
Coordinates 4492550..4492828 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH81_RS21090 (4488008) 4488008..4488832 + 825 WP_048215145.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
GZH81_RS21095 (4488901) 4488901..4490124 + 1224 WP_212024508.1 L-sorbose 1-phosphate reductase -
GZH81_RS21100 (4490126) 4490126..4490938 + 813 WP_212024510.1 shikimate 5-dehydrogenase -
GZH81_RS22800 (4490988) 4490988..4491149 - 162 WP_249219962.1 hypothetical protein -
GZH81_RS21110 (4491425) 4491425..4491976 + 552 WP_060683077.1 AAA family ATPase -
GZH81_RS21115 (4492240) 4492240..4492557 + 318 WP_032942059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZH81_RS21120 (4492550) 4492550..4492828 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
GZH81_RS21125 (4492939) 4492939..4493628 + 690 WP_032942056.1 dipeptidase PepE -
GZH81_RS21130 (4493795) 4493795..4495426 - 1632 WP_048213962.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11993.00 Da        Isoelectric Point: 9.6790

>T149344 WP_032942059.1 NZ_CP048388:4492240-4492557 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEIFCHE

Download         Length: 318 bp

>T149344 NZ_CP064005:c1781044-1780787 [Xanthomonas translucens pv. translucens]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATTCAACGCGATCCCTTCCAGGGCGTCGGCAAGCCAGAACGGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTCTACAAGGTCGAGGCGGGCGTCCTACTGATCGCGCAGGTG
CGGTATCACTACGCGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT149344 WP_032942057.1 NZ_CP048388:4492550-4492828 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT149344 NZ_CP064005:c1781292-1781041 [Xanthomonas translucens pv. translucens]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGTGTCGTCAACAATCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTAGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T4T9

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References