Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 3753519..3754261 Replicon chromosome
Accession NZ_CP048388
Organism Citrobacter portucalensis strain PNUCL1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag GZH81_RS17715 Protein ID WP_212024250.1
Coordinates 3753519..3753884 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GZH81_RS17720 Protein ID WP_212024252.1
Coordinates 3753905..3754261 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH81_RS17695 (3748689) 3748689..3749138 + 450 WP_032942441.1 GNAT family N-acetyltransferase -
GZH81_RS17700 (3749306) 3749306..3750310 + 1005 WP_212024246.1 LacI family DNA-binding transcriptional regulator -
GZH81_RS17705 (3750464) 3750464..3751915 + 1452 WP_212024248.1 Na+/H+ antiporter NhaC -
GZH81_RS17710 (3751928) 3751928..3753109 + 1182 WP_048226420.1 MalY/PatB family protein -
GZH81_RS17715 (3753519) 3753519..3753884 - 366 WP_212024250.1 TA system toxin CbtA family protein Toxin
GZH81_RS17720 (3753905) 3753905..3754261 - 357 WP_212024252.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZH81_RS17725 (3754287) 3754287..3754508 - 222 WP_212024254.1 DUF987 domain-containing protein -
GZH81_RS17730 (3754505) 3754505..3755047 - 543 WP_112047751.1 DNA repair protein RadC -
GZH81_RS17735 (3755060) 3755060..3755503 - 444 WP_212024255.1 antirestriction protein -
GZH81_RS17740 (3755534) 3755534..3756355 - 822 WP_212024257.1 DUF932 domain-containing protein -
GZH81_RS17745 (3756476) 3756476..3756949 - 474 WP_212024259.1 hypothetical protein -
GZH81_RS17750 (3757021) 3757021..3757473 - 453 WP_103847990.1 hypothetical protein -
GZH81_RS17755 (3757509) 3757509..3758225 - 717 WP_103847991.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3746189..3790590 44401


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13845.04 Da        Isoelectric Point: 7.7278

>T149341 WP_212024250.1 NZ_CP048388:c3753884-3753519 [Citrobacter portucalensis]
MKFLPARNMRAAEPCLSPVAVWQMLLKHLLEQHYGLTLNDTPFCDETVIQEHINAGITLANAVNFLVEKYELVRIDRNGF
TLQERTPYLTVTDILHARRACGLINSCSYREVSNIVLSRSR

Download         Length: 366 bp

>T149341 NZ_CP064005:143286-144542 [Xanthomonas translucens pv. translucens]
ATGAAAGGAAAGATAAGTAATGCATGCAAGCCAGACATCACTCCCATTCTTGTGGATGGCTTAGCATCGACAGCAACGCA
AGGTGCCGCAGATGACTCGGCTTCCAGGCTGCCACAGCAGGCGTTGCTTGATGGTCTGCAGGAAAGGCCGCAGGCCCTTA
AAAAATCCAATTCGGCCGATTGGTCTGCTCGCACTCTCCCGCAATGGGCGCCGGGTCCAGGGACATCATCAAAAGCCCTG
CTGATCCAATCGCCTCCTCACCCCACAAGTTCAGACGAGATGTTTGGACTGGGTGAGCTTCCAGCGCCCGGAAAAGCCCG
ATGGGAATATCTTACGAAAACCGAGAACTGGCATCCAGAGCGCCAGGAATTGCATAGCCGGCTATTGAGCCAAGCACGAA
CTGCATCCCTGCGCTTGGCCGAATCAATTGAGAGCGACGGCTACCCACCAACATTGTTCGCATTACGAGGCAATACTGCC
ACTGGTAAGACGCGTATAGCGACAAAGACGATTCCTGTGCTCGCAAATGCGCTCAAGAAGAGCAGTGGCGGCGGCTGCAT
TAATCCTGACATCTTTAAACGTTCACTAGCGGAATCGCAAGGAGAAGCAATGAAACTCAGTTCGGCGCAGGTACACGCCG
AATCATGCGTCCTCGCCGATCGGCTTGAAAACGAGCTTCGCTCGCAAAGGACCACAAGCGGTGCAATGGCCAGCATACTC
GTCGACAAACGACTGGCAAACACGCATGAGGTCGACAGCTACGTCAGTTTAGCCAAGGAGACAGGGCGCAAGGTCGAGTT
GTGCGATATCGATGCGCCTCTTGAGCGATCCCTTATGGGCGTACTTCAGAGAAGTCCGGGAGGTGATGATCCACGACCGC
CTTACGTGGCGGTTGCGAATGGATTTTCGACTGTCCGGAGCAACCGCTTAGATGTCATCGACAGGTTCCTGTCAAATCCA
ACCTTGGGAAGTTATCGCCTGTTCGGCACGAATGAAAAGGGTGAAAAAGTGATGGTTGCCAGCGTCGCCGATGGCGAACT
CAGCATTCACGACCCCCAGTTGTATGAGAGCATTACAGCTCCCGAGGACTTCAACTCGGGTGACAAAGGAGAACAGGTAA
TCGACACAGCGCTGATTGACCGTTTGAGCAACAGCATCGATGATCCAAAGCGTGCAACGGATGCACGTGCCGCCCTGGAG
AAATACAAGGGAATGACGTGGTCAAATGCTCTAGCGGCACACAGCTCATTGATCTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13270.86 Da        Isoelectric Point: 5.0359

>AT149341 WP_212024252.1 NZ_CP048388:c3754261-3753905 [Citrobacter portucalensis]
MNNHSESDTRPENPACQQWGLQSTITPCFDARLVQEGNRLHFLADRAGFNGAFSDEHALRLDQAFPLILKQLELMLTSGE
LNPQYQHCVTLYHNGLPCEADTLGSCGYVYIAVYPTQR

Download         Length: 357 bp

>AT149341 NZ_CP064005:144556-144852 [Xanthomonas translucens pv. translucens]
ATGACCCACTTAAAAGGCGCAGATGCACTTGCCCTGCATAAGAAACTCAAGGAGCGCAATGCCTCATTACGCAGTGCCGA
ACTTGATTCAGCAAAGGCGCTAGCCCATGAAAGCGGCAAAGAGCGCTTCAACCTCGAAAAATTGGAGAGCATTTGCGACA
CCACTCAAGCAGGGCGCATTACCGACCCGAACGATCGTCAGGCCATTTACGAACAAATGTATTATGTCGAGCATCCCAAA
GTCAGCACCTTGCAAGAATTCGCCCGCATTGTGGTGACGATTTCCTCATGGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References