Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3564041..3564661 Replicon chromosome
Accession NZ_CP048388
Organism Citrobacter portucalensis strain PNUCL1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GZH81_RS16840 Protein ID WP_002892050.1
Coordinates 3564443..3564661 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag GZH81_RS16835 Protein ID WP_003021733.1
Coordinates 3564041..3564415 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH81_RS16825 (3559187) 3559187..3560380 + 1194 WP_032942549.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GZH81_RS16830 (3560403) 3560403..3563552 + 3150 WP_008783964.1 efflux RND transporter permease AcrB -
GZH81_RS16835 (3564041) 3564041..3564415 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
GZH81_RS16840 (3564443) 3564443..3564661 + 219 WP_002892050.1 HHA domain-containing protein Toxin
GZH81_RS16845 (3564843) 3564843..3565394 + 552 WP_003835924.1 maltose O-acetyltransferase -
GZH81_RS16850 (3565511) 3565511..3565981 + 471 WP_063941318.1 YlaC family protein -
GZH81_RS16855 (3566060) 3566060..3566200 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
GZH81_RS16860 (3566202) 3566202..3566462 - 261 WP_008783961.1 type B 50S ribosomal protein L31 -
GZH81_RS16865 (3566651) 3566651..3568204 + 1554 WP_195995189.1 EAL domain-containing protein -
GZH81_RS16870 (3568256) 3568256..3568609 - 354 WP_048226278.1 DUF1428 family protein -
GZH81_RS16875 (3568674) 3568674..3569303 - 630 WP_048226280.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T149340 WP_002892050.1 NZ_CP048388:3564443-3564661 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T149340 NZ_CP064004:c4213159-4211903 [Xanthomonas translucens pv. translucens]
ATGAAAGGAAAGATAAGTAATGCATGCAAGCCAGACATCACTCCCATTCTTGTGGATGGCTTAGCATCGACAGCAACGCA
AGGTGCCGCAGATGACTCGGCTTCCAGGCTGCCACAGCAGGCGTTGCTTGATGGTCTGCAGGAAAGGCCGCAGGCCCTTA
AAAAATCCAATTCGGCCGATTGGTCTGCTCGCACTCTCCCGCAATGGGCGCCGGGTCCAGGGACATCATCAAAAGCCCTG
CTGATCCAATCGCCTCCTCACCCCACAAGTTCAGACGAGATGTTTGGACTGGGTGAGCTTCCAGCGCCCGGAAAAGCCCG
ATGGGAATATCTTACGAAAACCGAGAACTGGCATCCAGAGCGCCAGGAATTGCATAGCCGGCTATTGAGCCAAGCACGAA
CTGCATCCCTGCGCTTGGCCGAATCAATTGAGAGCGACGGCTACCCACCAACATTGTTCGCATTACGAGGCAATACTGCC
ACTGGTAAGACGCGTATAGCGACAAAGACGATTCCTGTGCTCGCAAATGCGCTCAAGAAGAGCAGTGGCGGCGGCTGCAT
TAATCCTGACATCTTTAAACGTTCACTAGCGGAATCGCAAGGAGAAGCAATGAAACTCAGTTCGGCGCAGGTACACGCCG
AATCATGCGTCCTCGCCGATCGGCTTGAAAACGAGCTTCGCTCGCAAAGGACCACAAGCGGTGCAATGGCCAGCATACTC
GTCGACAAACGACTGGCAAACACGCATGAGGTCGACAGCTACGTCAGTTTAGCCAAGGAGACAGGGCGCAAGGTCGAGTT
GTGCGATATCGATGCGCCTCTTGAGCGATCCCTTATGGGCGTACTTCAGAGAAGTCCGGGAGGTGATGATCCACGACCGC
CTTACGTGGCGGTTGCGAATGGATTTTCGACTGTCCGGAGCAACCGCTTAGATGTCATCGACAGGTTCCTGTCAAATCCA
ACCTTGGGAAGTTATCGCCTGTTCGGCACGAATGAAAATGGTGAAAAAGTGATGGTTGCCAGCGTCGCCGATGGCGAACT
CAGCATTCACGACCCCAAGTTGTATGAGAGCATTACAGCTCCCGAGGACTTCAACTCGGGTGACAAAGGAGAACAGGTAA
TCGACACAGCGCTGATTGACCGTTTGAGCAACAGCATCGATGATCCAAAGCGTGCAACGGATGCACGTGCCGCCCTGGAG
AAATACAAGGGAATGACGTGGTCAAATGCTCTAGCGGCACACAGTTCATTGATCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT149340 WP_003021733.1 NZ_CP048388:3564041-3564415 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT149340 NZ_CP064004:c4211889-4211593 [Xanthomonas translucens pv. translucens]
ATGACCCACTTAAAAGGCGCAGATGCACTTGCCCTGCATAAGAAACTCAAGGAGCGCAATGCCGCATTACGCAGTGCCGA
ACTTGATTCAGCAAAGGCGCTAGCCCATGAAAGCGGCAAAGAGCGCTTCAACCTCGAAAAATTGGAGAGCATTTGCGACA
CCACTCAAGCAGGGCGCATTACCGACCCGAACGATCGTCAGGCCATTTACGAACAAATGTATTATGTCGAGCATCCCAAA
GTCAGCACCTTGCAAGAATTCGCCCGCATTGTGGTGACGATTTCCTCATGGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References