Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2121752..2122268 Replicon chromosome
Accession NZ_CP048382
Organism Citrobacter freundii strain 62

Toxin (Protein)


Gene name relE Uniprot ID A0A0J1MTE6
Locus tag GZS04_RS10160 Protein ID WP_016149473.1
Coordinates 2121984..2122268 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag GZS04_RS10155 Protein ID WP_003839576.1
Coordinates 2121752..2121994 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS04_RS10135 2116767..2117900 + 1134 WP_060855415.1 amidohydrolase/deacetylase family metallohydrolase -
GZS04_RS10140 2117884..2119002 + 1119 WP_048219848.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
GZS04_RS10145 2118999..2119739 + 741 WP_003025772.1 KDGP aldolase family protein -
GZS04_RS10150 2119761..2121674 + 1914 WP_003839574.1 BglG family transcription antiterminator -
GZS04_RS10155 2121752..2121994 + 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GZS04_RS10160 2121984..2122268 + 285 WP_016149473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZS04_RS10165 2122272..2122736 - 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GZS04_RS10170 2122843..2124981 - 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
GZS04_RS10175 2125390..2127042 - 1653 WP_016149475.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.73 Da        Isoelectric Point: 10.0482

>T149310 WP_016149473.1 NZ_CP048382:2121984-2122268 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T149310 NZ_CP063996:c3902846-3902712 [Xanthomonas translucens pv. undulosa]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT149310 WP_003839576.1 NZ_CP048382:2121752-2121994 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT149310 NZ_CP063996:c3903097-3902945 [Xanthomonas translucens pv. undulosa]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MTE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References