Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 1714188..1714804 | Replicon | chromosome |
Accession | NZ_CP048382 | ||
Organism | Citrobacter freundii strain 62 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0J1MQ96 |
Locus tag | GZS04_RS08255 | Protein ID | WP_003028682.1 |
Coordinates | 1714430..1714804 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A6B5NTK4 |
Locus tag | GZS04_RS08250 | Protein ID | WP_043018956.1 |
Coordinates | 1714188..1714430 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GZS04_RS08225 | 1710038..1710637 | + | 600 | WP_046671351.1 | glucose-1-phosphatase | - |
GZS04_RS08230 | 1710631..1711503 | + | 873 | WP_003028669.1 | virulence factor BrkB family protein | - |
GZS04_RS08235 | 1711500..1711937 | + | 438 | WP_003028671.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
GZS04_RS08240 | 1711982..1712923 | + | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
GZS04_RS08245 | 1713074..1713982 | - | 909 | WP_046671350.1 | alpha/beta hydrolase | - |
GZS04_RS08250 | 1714188..1714430 | + | 243 | WP_043018956.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
GZS04_RS08255 | 1714430..1714804 | + | 375 | WP_003028682.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
GZS04_RS08260 | 1714841..1715770 | - | 930 | WP_003028685.1 | formate dehydrogenase accessory protein FdhE | - |
GZS04_RS08265 | 1715767..1716402 | - | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
GZS04_RS08270 | 1716399..1717301 | - | 903 | WP_003028691.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13674.89 Da Isoelectric Point: 9.5622
>T149307 WP_003028682.1 NZ_CP048382:1714430-1714804 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
Download Length: 375 bp
>T149307 NZ_CP063996:c2196741-2196322 [Xanthomonas translucens pv. undulosa]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAACCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTTGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAAAAAGGCCTGGGCGAAGCCCTGGACGGATTGCTCGAACTGTTCAGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCAATTATGCCGAGCTGGCGGTGAAGGCCCGTATAGCCGGGAAGGGTTTTCCAACACCCGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTGGCAACACGCGACACCAGCCCTTTTGAAGCGGCCGGGCTTACTGTTATCA
ATCCTTGGAACCATCGGTAA
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAACCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTTGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAAAAAGGCCTGGGCGAAGCCCTGGACGGATTGCTCGAACTGTTCAGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCAATTATGCCGAGCTGGCGGTGAAGGCCCGTATAGCCGGGAAGGGTTTTCCAACACCCGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTGGCAACACGCGACACCAGCCCTTTTGAAGCGGCCGGGCTTACTGTTATCA
ATCCTTGGAACCATCGGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9451.75 Da Isoelectric Point: 4.3437
>AT149307 WP_043018956.1 NZ_CP048382:1714188-1714430 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW
Download Length: 243 bp
>AT149307 NZ_CP063996:c2196992-2196738 [Xanthomonas translucens pv. undulosa]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGACGAGGTACATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTCCGCGAGATTCTGGAGAGTGCAGTTAAGTCACAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCGCGTAGGGCTAACAAATGATGATTTCGCAGTATTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA
ATGGCAATCCTGACAGTGCGGAATGTGCCCGACGAGGTACATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTCCGCGAGATTCTGGAGAGTGCAGTTAAGTCACAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCGCGTAGGGCTAACAAATGATGATTTCGCAGTATTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1MQ96 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B5NTK4 |