Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 726628..727282 Replicon chromosome
Accession NZ_CP048382
Organism Citrobacter freundii strain 62

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag GZS04_RS03430 Protein ID WP_003026936.1
Coordinates 726628..727035 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag GZS04_RS03435 Protein ID WP_003026938.1
Coordinates 727016..727282 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS04_RS03410 722576..724309 - 1734 WP_054528765.1 single-stranded-DNA-specific exonuclease RecJ -
GZS04_RS03415 724315..725028 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GZS04_RS03420 725052..725948 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
GZS04_RS03425 726062..726583 + 522 WP_003026933.1 flavodoxin FldB -
GZS04_RS03430 726628..727035 - 408 WP_003026936.1 protein YgfX Toxin
GZS04_RS03435 727016..727282 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
GZS04_RS03440 727539..728519 + 981 WP_119174530.1 tRNA-modifying protein YgfZ -
GZS04_RS03445 728613..729272 - 660 WP_003026947.1 hemolysin III family protein -
GZS04_RS03450 729435..729746 - 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
GZS04_RS03455 729799..730527 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
GZS04_RS03460 730648..732081 + 1434 WP_162648171.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T149304 WP_003026936.1 NZ_CP048382:c727035-726628 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T149304 NZ_CP063993:2666006-2666158 [Xanthomonas translucens pv. undulosa]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT149304 WP_003026938.1 NZ_CP048382:c727282-727016 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT149304 NZ_CP063993:2666257-2666391 [Xanthomonas translucens pv. undulosa]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References