Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1874654..1875486 Replicon chromosome
Accession NZ_CP048371
Organism Escherichia coli strain 163

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag GZS08_RS08845 Protein ID WP_000854765.1
Coordinates 1874654..1875028 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag GZS08_RS08850 Protein ID WP_001295723.1
Coordinates 1875118..1875486 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS08_RS08805 1870039..1870221 - 183 WP_001016348.1 hypothetical protein -
GZS08_RS08815 1870675..1871064 - 390 WP_001445118.1 IS110 family transposase -
GZS08_RS08820 1871558..1871962 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
GZS08_RS08825 1871959..1872306 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
GZS08_RS08830 1872355..1873890 + 1536 WP_001333339.1 IS66-like element ISEc22 family transposase -
GZS08_RS08835 1874325..1874438 - 114 WP_001161660.1 DUF957 domain-containing protein -
GZS08_RS08840 1874451..1874657 - 207 WP_000976829.1 hypothetical protein -
GZS08_RS08845 1874654..1875028 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
GZS08_RS08850 1875118..1875486 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZS08_RS08855 1875649..1875870 - 222 WP_000692341.1 DUF987 domain-containing protein -
GZS08_RS08860 1875933..1876409 - 477 WP_001186774.1 RadC family protein -
GZS08_RS08865 1876425..1876898 - 474 WP_000855059.1 antirestriction protein -
GZS08_RS08870 1877240..1878058 - 819 WP_001234729.1 DUF945 domain-containing protein -
GZS08_RS08875 1878213..1878371 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T149255 WP_000854765.1 NZ_CP048371:c1875028-1874654 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T149255 NZ_CP063980:c586581-586438 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT149255 WP_001295723.1 NZ_CP048371:c1875486-1875118 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT149255 NZ_CP063980:c586294-586245 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References