Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3866492..3867245 Replicon chromosome
Accession NZ_CP048359
Organism Escherichia coli strain 53

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GZS09_RS18570 Protein ID WP_040064419.1
Coordinates 3866868..3867245 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GZS09_RS18565 Protein ID WP_172803453.1
Coordinates 3866492..3866818 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS09_RS25655 3861723..3861872 + 150 WP_001458941.1 hypothetical protein -
GZS09_RS18520 3861884..3862099 + 216 WP_040064431.1 hypothetical protein -
GZS09_RS18525 3862244..3862654 + 411 WP_060615797.1 hypothetical protein -
GZS09_RS18530 3862720..3863658 + 939 WP_077870123.1 hypothetical protein -
GZS09_RS18535 3863732..3863965 + 234 WP_040064428.1 DUF905 domain-containing protein -
GZS09_RS18540 3864076..3864897 + 822 WP_162647494.1 DUF945 domain-containing protein -
GZS09_RS18545 3864897..3865151 + 255 WP_060615795.1 hypothetical protein -
GZS09_RS18550 3865247..3865714 + 468 WP_040064426.1 antirestriction protein -
GZS09_RS18555 3865725..3866204 + 480 WP_040064425.1 DNA repair protein RadC -
GZS09_RS18560 3866215..3866436 + 222 WP_060615794.1 DUF987 family protein -
GZS09_RS18565 3866492..3866818 + 327 WP_172803453.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZS09_RS18570 3866868..3867245 + 378 WP_040064419.1 TA system toxin CbtA family protein Toxin
GZS09_RS18575 3867242..3867733 + 492 WP_060615793.1 hypothetical protein -
GZS09_RS18580 3867763..3867966 + 204 WP_040064417.1 DUF957 domain-containing protein -
GZS09_RS18585 3868047..3868898 + 852 WP_060615792.1 DUF4942 domain-containing protein -
GZS09_RS18595 3869229..3869960 - 732 WP_001297205.1 DNA polymerase III subunit epsilon -
GZS09_RS18600 3870025..3870492 + 468 WP_000917883.1 ribonuclease HI -
GZS09_RS18605 3870489..3871211 - 723 WP_001295200.1 class I SAM-dependent methyltransferase -
GZS09_RS18610 3871245..3872000 + 756 WP_001052707.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14092.01 Da        Isoelectric Point: 8.1110

>T149192 WP_040064419.1 NZ_CP048359:3866868-3867245 [Escherichia coli]
MQTQPAPPKREVSPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDSVIHEHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SAETHSPLLTSIDILRARKATGLMTRNGYKVVTDITTGKYRGVQQ

Download         Length: 378 bp

>T149192 NZ_CP063943:329036-329446 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12197.90 Da        Isoelectric Point: 6.9559

>AT149192 WP_172803453.1 NZ_CP048359:3866492-3866818 [Escherichia coli]
IAEPWWGLKRNITPCFGARLVQEGNRLHYLNDRASITGRFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHCVTLYA
KGLTCESDTLGSHGYVYLAIYPTPATTE

Download         Length: 327 bp

>AT149192 NZ_CP063943:328789-329055 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References