Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1810704..1811539 Replicon chromosome
Accession NZ_CP048359
Organism Escherichia coli strain 53

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GZS09_RS08610 Protein ID WP_001614648.1
Coordinates 1810704..1811081 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GZS09_RS08615 Protein ID WP_032286518.1
Coordinates 1811171..1811539 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS09_RS08570 1806091..1807257 + 1167 WP_085668764.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
GZS09_RS08575 1807376..1807849 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
GZS09_RS08580 1808047..1809105 + 1059 WP_085668766.1 FUSC family protein -
GZS09_RS08585 1809277..1809606 + 330 WP_000450409.1 DUF496 family protein -
GZS09_RS08590 1809707..1809889 - 183 WP_001016348.1 hypothetical protein -
GZS09_RS08595 1809961..1810089 + 129 Protein_1681 transposase domain-containing protein -
GZS09_RS08600 1810378..1810491 - 114 WP_001161660.1 DUF957 domain-containing protein -
GZS09_RS08605 1810504..1810707 - 204 WP_000761705.1 hypothetical protein -
GZS09_RS08610 1810704..1811081 - 378 WP_001614648.1 TA system toxin CbtA family protein Toxin
GZS09_RS08615 1811171..1811539 - 369 WP_032286518.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZS09_RS08620 1811702..1811923 - 222 WP_032286237.1 DUF987 domain-containing protein -
GZS09_RS08625 1811986..1812462 - 477 WP_085668768.1 RadC family protein -
GZS09_RS08630 1812478..1812951 - 474 WP_001411480.1 antirestriction protein -
GZS09_RS08635 1813045..1813293 - 249 WP_032286278.1 hypothetical protein -
GZS09_RS08640 1813293..1814111 - 819 WP_032286280.1 DUF945 domain-containing protein -
GZS09_RS08645 1814266..1814424 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14079.08 Da        Isoelectric Point: 7.2919

>T149179 WP_001614648.1 NZ_CP048359:c1811081-1810704 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T149179 NZ_CP063939:c3169681-3169148 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13536.20 Da        Isoelectric Point: 5.4492

>AT149179 WP_032286518.1 NZ_CP048359:c1811539-1811171 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT149179 NZ_CP063939:c3169958-3169692 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References