Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3295406..3296111 Replicon chromosome
Accession NZ_CP048337
Organism Escherichia coli strain 142

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag GZS12_RS15730 Protein ID WP_000539521.1
Coordinates 3295406..3295792 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GZS12_RS15735 Protein ID WP_001280945.1
Coordinates 3295782..3296111 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS12_RS15710 3291410..3292036 + 627 WP_001295292.1 glutathione S-transferase GstB -
GZS12_RS15715 3292033..3293148 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
GZS12_RS15720 3293259..3293642 - 384 WP_000497137.1 biofilm formation regulator BssR -
GZS12_RS15725 3293855..3295180 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
GZS12_RS15730 3295406..3295792 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZS12_RS15735 3295782..3296111 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
GZS12_RS15740 3296181..3297509 - 1329 WP_022645414.1 GGDEF domain-containing protein -
GZS12_RS15745 3297517..3299865 - 2349 WP_162646430.1 EAL domain-containing protein -
GZS12_RS15750 3300042..3300953 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T149120 WP_000539521.1 NZ_CP048337:3295406-3295792 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T149120 NZ_CP063930:4513936-4514038 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT149120 WP_001280945.1 NZ_CP048337:3295782-3296111 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT149120 NZ_CP063930:c4514045-4513900 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References