Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1946654..1947485 Replicon chromosome
Accession NZ_CP048337
Organism Escherichia coli strain 142

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6C9I6Z5
Locus tag GZS12_RS09095 Protein ID WP_001563930.1
Coordinates 1946654..1947028 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag GZS12_RS09100 Protein ID WP_001285585.1
Coordinates 1947117..1947485 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS12_RS09055 1942050..1943216 + 1167 WP_001563931.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
GZS12_RS09060 1943335..1943808 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
GZS12_RS09065 1944006..1945064 + 1059 WP_001200891.1 FUSC family protein -
GZS12_RS09070 1945236..1945565 + 330 WP_000450409.1 DUF496 family protein -
GZS12_RS09075 1945666..1945848 - 183 WP_001016348.1 hypothetical protein -
GZS12_RS09080 1945920..1946048 + 129 Protein_1776 transposase domain-containing protein -
GZS12_RS09085 1946337..1946450 - 114 WP_001161660.1 DUF957 domain-containing protein -
GZS12_RS09090 1946463..1946657 - 195 WP_000988600.1 hypothetical protein -
GZS12_RS09095 1946654..1947028 - 375 WP_001563930.1 type IV toxin-antitoxin system toxin CbtA Toxin
GZS12_RS09100 1947117..1947485 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GZS12_RS09105 1947559..1947780 - 222 WP_000692323.1 DUF987 domain-containing protein -
GZS12_RS09110 1947843..1948319 - 477 WP_023910200.1 RadC family protein -
GZS12_RS09115 1948335..1948820 - 486 WP_000214393.1 antirestriction protein -
GZS12_RS09120 1948911..1949729 - 819 WP_162646410.1 DUF945 domain-containing protein -
GZS12_RS09125 1949829..1950062 - 234 WP_001119729.1 DUF905 family protein -
GZS12_RS09130 1950141..1950596 - 456 WP_162646399.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13883.97 Da        Isoelectric Point: 7.8522

>T149109 WP_001563930.1 NZ_CP048337:c1947028-1946654 [Escherichia coli]
MKTLPVLPGLAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T149109 NZ_CP063929:c138495-138337 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT149109 WP_001285585.1 NZ_CP048337:c1947485-1947117 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT149109 NZ_CP063929:c138763-138539 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9I6Z5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References