Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 851845..852680 Replicon chromosome
Accession NZ_CP048337
Organism Escherichia coli strain 142

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2I6T1R7
Locus tag GZS12_RS04020 Protein ID WP_016231184.1
Coordinates 851845..852222 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7Z1I923
Locus tag GZS12_RS04025 Protein ID WP_016231183.1
Coordinates 852312..852680 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS12_RS03990 846959..848107 - 1149 WP_000905926.1 capsule polysaccharide export inner-membrane protein KpsE -
GZS12_RS03995 848179..849162 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
GZS12_RS04000 849973..850143 - 171 Protein_785 IS110 family transposase -
GZS12_RS04005 850485..851054 - 570 WP_016231187.1 DUF4942 domain-containing protein -
GZS12_RS04010 851151..851348 - 198 WP_016231186.1 DUF957 domain-containing protein -
GZS12_RS04015 851360..851848 - 489 WP_016231185.1 hypothetical protein -
GZS12_RS04020 851845..852222 - 378 WP_016231184.1 TA system toxin CbtA family protein Toxin
GZS12_RS04025 852312..852680 - 369 WP_016231183.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZS12_RS04030 852730..853218 - 489 WP_021824123.1 hypothetical protein -
GZS12_RS26040 853231..853374 - 144 WP_001521299.1 hypothetical protein -
GZS12_RS04035 853393..853614 - 222 WP_016231182.1 DUF987 domain-containing protein -
GZS12_RS04040 853677..854153 - 477 WP_001186774.1 RadC family protein -
GZS12_RS04045 854169..854654 - 486 WP_000849596.1 antirestriction protein -
GZS12_RS04050 854709..855527 - 819 WP_023909039.1 DUF945 domain-containing protein -
GZS12_RS04055 855627..855860 - 234 WP_001119719.1 DUF905 family protein -
GZS12_RS04060 855946..856350 + 405 WP_016231180.1 IS66 family insertion sequence hypothetical protein -
GZS12_RS04065 856347..856694 + 348 WP_000612617.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14106.07 Da        Isoelectric Point: 8.2905

>T149105 WP_016231184.1 NZ_CP048337:c852222-851845 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T149105 NZ_CP063928:199004-199474 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13613.43 Da        Isoelectric Point: 6.8413

>AT149105 WP_016231183.1 NZ_CP048337:c852680-852312 [Escherichia coli]
MSDTLPGTTLPDNNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT149105 NZ_CP063928:198564-199007 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I6T1R7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1I923

References