Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2283718..2284244 | Replicon | chromosome |
| Accession | NZ_CP048330 | ||
| Organism | Escherichia coli strain 10 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | GZS13_RS11060 | Protein ID | WP_000323025.1 |
| Coordinates | 2283957..2284244 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | GZS13_RS11055 | Protein ID | WP_000534858.1 |
| Coordinates | 2283718..2283957 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GZS13_RS11020 | 2279125..2279424 | - | 300 | WP_039720394.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| GZS13_RS11025 | 2279421..2279825 | - | 405 | WP_000839179.1 | IS66 family insertion sequence hypothetical protein | - |
| GZS13_RS25215 | 2280047..2280334 | + | 288 | Protein_2148 | hypothetical protein | - |
| GZS13_RS11040 | 2281103..2282416 | + | 1314 | WP_162656861.1 | ISNCY family transposase | - |
| GZS13_RS11045 | 2282853..2283185 | - | 333 | WP_001301033.1 | protein FlxA | - |
| GZS13_RS11050 | 2283388..2283693 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| GZS13_RS11055 | 2283718..2283957 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| GZS13_RS11060 | 2283957..2284244 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| GZS13_RS11065 | 2284316..2284471 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| GZS13_RS11070 | 2284688..2284939 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| GZS13_RS11075 | 2285006..2285284 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| GZS13_RS11080 | 2285286..2286335 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| GZS13_RS11085 | 2286349..2287101 | + | 753 | WP_001047135.1 | antitermination protein | - |
| GZS13_RS11090 | 2287379..2287468 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| GZS13_RS11095 | 2287523..2287735 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| GZS13_RS11100 | 2288036..2288251 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| GZS13_RS11105 | 2289005..2289220 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2266823..2328824 | 62001 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T149085 WP_000323025.1 NZ_CP048330:2283957-2284244 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T149085 NZ_CP063926:2478866-2479084 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT149085 WP_000534858.1 NZ_CP048330:2283718-2283957 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT149085 NZ_CP063926:2478465-2478839 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|