Detailed information of TA system TA148984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4730278..4731098
• Replicon: chromosome
• Accession: NZ_CP048304
• Organism: Escherichia coli strain 9

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: GZS17_RS22485
• Protein ID: WP_001054379.1
• Coordinates: 4730278..4730535 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: GZS17_RS22490
• Protein ID: WP_000123957.1
• Coordinates: 4730547..4731098 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZS17_RS22465	4725909..4727015	+	1107	WP_001295733.1	N-acetylneuraminate epimerase	-
GZS17_RS22470	4727079..4728059	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
GZS17_RS22475	4728642..4729739	-	1098	Protein_4387	DNA helicase	-
GZS17_RS22480	4729740..4729901	+	162	Protein_4388	GNAT family N-acetyltransferase	-
GZS17_RS22485	4730278..4730535	+	258	WP_001054379.1	YjhX family toxin	Toxin
GZS17_RS22490	4730547..4731098	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
GZS17_RS22495	4731150..4731896	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
GZS17_RS22500	4732014..4732796	-	783	WP_001317493.1	IS21-like element IS100kyp family helper ATPase IstB	-
GZS17_RS22505	4732793..4733815	-	1023	WP_000255944.1	IS21-like element IS100 family transposase	-
GZS17_RS22510	4733983..4734243	+	261	WP_000077645.1	hypothetical protein	-
GZS17_RS26045	4734281..4734397	+	117	Protein_4395	VOC family protein	-
GZS17_RS22515	4734642..4735763	+	1122	WP_000010833.1	M42 family metallopeptidase	-
GZS17_RS22520	4735760..4736038	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T148984 WP_001054379.1 NZ_CP048304:4730278-4730535 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T148984 NZ_CP063912:3375772-3376119 [Klebsiella variicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT148984 WP_000123957.1 NZ_CP048304:4730547-4731098 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT148984 NZ_CP063912:3376119-3376418 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCACTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: B6I030