Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3587022..3587823 Replicon chromosome
Accession NZ_CP048304
Organism Escherichia coli strain 9

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag GZS17_RS17090 Protein ID WP_000854739.1
Coordinates 3587022..3587402 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag GZS17_RS17095 Protein ID WP_001285481.1
Coordinates 3587449..3587823 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS17_RS17060 3583694..3584398 + 705 WP_001241667.1 leucyl/phenylalanyl-tRNA--protein transferase -
GZS17_RS17065 3584683..3584901 + 219 WP_001040187.1 translation initiation factor IF-1 -
GZS17_RS17075 3585408..3586235 - 828 WP_001304477.1 DUF4942 domain-containing protein -
GZS17_RS17080 3586320..3586517 - 198 WP_000772027.1 DUF957 domain-containing protein -
GZS17_RS17085 3586537..3587025 - 489 WP_001054232.1 hypothetical protein -
GZS17_RS17090 3587022..3587402 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
GZS17_RS17095 3587449..3587823 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZS17_RS17100 3587873..3588517 - 645 WP_001617449.1 hypothetical protein -
GZS17_RS17105 3588536..3588757 - 222 WP_000692312.1 DUF987 domain-containing protein -
GZS17_RS17110 3588820..3589296 - 477 WP_001186170.1 RadC family protein -
GZS17_RS17115 3589312..3589785 - 474 WP_001313575.1 antirestriction protein -
GZS17_RS17120 3590048..3590869 - 822 WP_001234710.1 DUF945 domain-containing protein -
GZS17_RS17125 3590970..3591203 - 234 WP_000902034.1 DUF905 family protein -
GZS17_RS17130 3591282..3591737 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T148977 WP_000854739.1 NZ_CP048304:c3587402-3587022 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T148977 NZ_CP063911:4207972-4208289 [Klebsiella variicola]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT148977 WP_001285481.1 NZ_CP048304:c3587823-3587449 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT148977 NZ_CP063911:4208282-4208569 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References