Detailed information of TA system TA148957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 4762669..4763303
• Replicon: chromosome
• Accession: NZ_CP048286
• Organism: Paenibacillus rhizovicinus strain 14171R-81

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: GZH47_RS21360
• Protein ID: WP_125664969.1
• Coordinates: 4762953..4763303 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: GZH47_RS21355
• Protein ID: WP_090644307.1
• Coordinates: 4762669..4762950 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZH47_RS21345	4759385..4760677	+	1293	WP_162643071.1	outer membrane lipoprotein carrier protein LolA	-
GZH47_RS21350	4760951..4762147	+	1197	WP_162643072.1	alanine racemase	-
GZH47_RS21355	4762669..4762950	+	282	WP_090644307.1	ribbon-helix-helix protein, CopG family	Antitoxin
GZH47_RS21360	4762953..4763303	+	351	WP_125664969.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GZH47_RS21365	4763578..4764549	+	972	WP_162643073.1	ABC transporter permease subunit	-
GZH47_RS21370	4764571..4765458	+	888	WP_162643074.1	carbohydrate ABC transporter permease	-
GZH47_RS21375	4765527..4767284	+	1758	WP_162643075.1	extracellular solute-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12806.72 Da
• Isoelectric Point: 5.1284

>T148957 WP_125664969.1 NZ_CP048286:4762953-4763303 [Paenibacillus rhizovicinus]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAASHGFDRDSVLLLEQI
RTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF

Nucleotide

• Length: 351 bp

>T148957 NZ_CP063909:c127119-126676 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10593.22 Da
• Isoelectric Point: 7.0148

>AT148957 WP_090644307.1 NZ_CP048286:4762669-4762950 [Paenibacillus rhizovicinus]
VANLQNTKRIMISLPDHLLEEVDGIVAKENSNRSEFIRQAMKLYLIERKKRQIRDSMQRGYLEMAKINLVMASEAFQAEE
DAGDTLGRLVSGV

Nucleotide

• Length: 282 bp

>AT148957 NZ_CP063909:c127346-127116 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA