Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 376537..377207 Replicon plasmid pRle248d
Accession NZ_CP048282
Organism Rhizobium leguminosarum bv. viciae 248

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GYN07_RS30135 Protein ID WP_020052736.1
Coordinates 376537..376941 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GYN07_RS30140 Protein ID WP_020052737.1
Coordinates 376938..377207 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYN07_RS30115 372931..374145 - 1215 WP_026265574.1 polyhydroxyalkanoate depolymerase -
GYN07_RS30120 374269..374922 + 654 WP_026265575.1 glutathione S-transferase -
GYN07_RS30125 375039..375860 + 822 WP_020052734.1 (S)-ureidoglycine aminohydrolase -
GYN07_RS30130 375879..376412 + 534 WP_020052735.1 GNAT family N-acetyltransferase -
GYN07_RS30135 376537..376941 - 405 WP_020052736.1 type II toxin-antitoxin system VapC family toxin Toxin
GYN07_RS30140 376938..377207 - 270 WP_020052737.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GYN07_RS30145 377348..377566 - 219 WP_020052738.1 hypothetical protein -
GYN07_RS30150 377627..378472 - 846 WP_020052739.1 pirin family protein -
GYN07_RS30155 378739..379221 + 483 WP_026265576.1 DMT family transporter -
GYN07_RS30160 379218..379655 + 438 WP_020052741.1 DMT family transporter -
GYN07_RS30165 379769..380929 - 1161 WP_020052742.1 amidase -
GYN07_RS30170 380943..381650 - 708 WP_020052743.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..548709 548709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin

SpoVT-AbrB domain

(18-53)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14011.36 Da        Isoelectric Point: 5.8399

>T148955 WP_020052736.1 NZ_CP048282:c376941-376537 [Rhizobium leguminosarum bv. viciae 248]
MSKLYILDTNIVSELARNPRGVVAQRIAEVGPDAICVSIITASELRYGCVKKGSSKLLAQIEAILGSVAVLALDVPADAA
YGGIRAELEAAGKPIGPNDLFIAAQASALGAVLVTANVGEFMRIHALRVENWLV

Download         Length: 405 bp

>T148955 NZ_CP063909:c31370-31059 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10155.66 Da        Isoelectric Point: 5.6262

>AT148955 WP_020052737.1 NZ_CP048282:c377207-376938 [Rhizobium leguminosarum bv. viciae 248]
VAYSRHQEPIPPREAKLFRNNKSQAVRIPADFELPGDRVMIHRDGDRLIIEPVHRKNLLEVLAGLEPLGPDDQFPDVDDT
LLPVKKIDL

Download         Length: 270 bp

>AT148955 NZ_CP063909:c31062-30643 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References