Detailed information of TA system TA148949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 4477461..4477996
• Replicon: chromosome
• Accession: NZ_CP048280
• Organism: Rhizobium leguminosarum bv. viciae 248

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GYN07_RS22195
• Protein ID: WP_020052112.1
• Coordinates: 4477706..4477996 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GYN07_RS22190
• Protein ID: WP_026265506.1
• Coordinates: 4477461..4477709 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYN07_RS22175	4473079..4474101	-	1023	WP_020052107.1	galactose mutarotase	-
GYN07_RS22180	4474298..4475221	-	924	WP_020052109.1	homoserine O-succinyltransferase	-
GYN07_RS22185	4475462..4477354	+	1893	WP_020052110.1	ABC transporter ATP-binding protein/permease	-
GYN07_RS22190	4477461..4477709	+	249	WP_026265506.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GYN07_RS22195	4477706..4477996	+	291	WP_020052112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GYN07_RS22200	4478034..4478663	-	630	WP_020052113.1	hypothetical protein	-
GYN07_RS22205	4478782..4480599	-	1818	WP_020052114.1	ABC-F family ATP-binding cassette domain-containing protein	-
GYN07_RS22210	4480603..4481259	-	657	WP_020052115.1	thiamine diphosphokinase	-
GYN07_RS22215	4481317..4481844	-	528	WP_026265507.1	MarR family winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11427.90 Da
• Isoelectric Point: 4.5594

>T148949 WP_020052112.1 NZ_CP048280:4477706-4477996 [Rhizobium leguminosarum bv. viciae 248]
MKYRTTIEADQDIVELYILGADQFGALQSEQYVDDLFDTFELLADNPRMARERRELNPPTRLHPYRAHMIAYTIREEDIL
IVRVLHGREDWQSLFS

Nucleotide

• Length: 291 bp

>T148949 NZ_CP063908:c3355033-3354623 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9348.56 Da
• Isoelectric Point: 9.7724

>AT148949 WP_026265506.1 NZ_CP048280:4477461-4477709 [Rhizobium leguminosarum bv. viciae 248]
MATMNVSLPDPMKEWVDAQTKTGRYSNASDYVRDLIRRDQERAGKLAELQRLITDGLESGVSDRSKADILREARERLAAR
RV

Nucleotide

• Length: 249 bp

>AT148949 NZ_CP063908:c3355280-3355014 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA