Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4364046..4364578 Replicon chromosome
Accession NZ_CP048280
Organism Rhizobium leguminosarum bv. viciae 248

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GYN07_RS21645 Protein ID WP_020052016.1
Coordinates 4364046..4364336 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A179C0U9
Locus tag GYN07_RS21650 Protein ID WP_020052017.1
Coordinates 4364333..4364578 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYN07_RS21620 4360001..4360432 + 432 WP_020052011.1 hypothetical protein -
GYN07_RS21625 4360532..4361173 - 642 WP_020052012.1 LysE family translocator -
GYN07_RS21630 4361397..4361771 - 375 WP_020052013.1 helix-turn-helix transcriptional regulator -
GYN07_RS21635 4361859..4362476 + 618 WP_020052014.1 NAD(P)H-dependent oxidoreductase -
GYN07_RS21640 4362716..4363939 - 1224 WP_020052015.1 argininosuccinate synthase -
GYN07_RS21645 4364046..4364336 - 291 WP_020052016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GYN07_RS21650 4364333..4364578 - 246 WP_020052017.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GYN07_RS21655 4364665..4365516 + 852 WP_020052018.1 SDR family NAD(P)-dependent oxidoreductase -
GYN07_RS21660 4365601..4366242 + 642 WP_020052019.1 LysE family translocator -
GYN07_RS21665 4366290..4367084 - 795 WP_020052020.1 ABC transporter ATP-binding protein -
GYN07_RS21670 4367081..4367959 - 879 WP_017989717.1 ABC transporter permease -
GYN07_RS21675 4368089..4369042 - 954 WP_020052021.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(2-77)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11010.79 Da        Isoelectric Point: 9.6934

>T148948 WP_020052016.1 NZ_CP048280:c4364336-4364046 [Rhizobium leguminosarum bv. viciae 248]
MKALVLSPAAVDDLDRIYDYTEEKWGQGQAEDYIVALRGYCEALAAQTKRGRKIIRLRSGYTALAFRSHFVIYAETEKVL
TVIRILHRRMNIAAHL

Download         Length: 291 bp

>T148948 NZ_CP063908:c2113357-2113255 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8956.07 Da        Isoelectric Point: 4.6677

>AT148948 WP_020052017.1 NZ_CP048280:c4364578-4364333 [Rhizobium leguminosarum bv. viciae 248]
VAKVVSIRIDDHMEEFIGNQLDQGAYGSADEVIDAGLRLLQREAELAAIEAAIIEGEKSGKPRPFDFDAFIEGKRARRGR
Q

Download         Length: 246 bp

>AT148948 NZ_CP063908:2113248-2113393 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A179C0U9

References