Detailed information of TA system TA148942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2735707..2736203
• Replicon: chromosome
• Accession: NZ_CP048279
• Organism: Staphylococcus sp. MI 10-1553

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GZH82_RS13035
• Protein ID: WP_162682829.1
• Coordinates: 2735707..2735979 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GZH82_RS13040
• Protein ID: WP_162682830.1
• Coordinates: 2735976..2736203 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZH82_RS13020	2731389..2732123	-	735	WP_162682826.1	trehalose operon repressor	-
GZH82_RS13025	2732146..2733777	-	1632	WP_162682827.1	alpha,alpha-phosphotrehalase	-
GZH82_RS13030	2733818..2735260	-	1443	WP_162682828.1	PTS system trehalose-specific EIIBC component	-
GZH82_RS13035	2735707..2735979	-	273	WP_162682829.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GZH82_RS13040	2735976..2736203	-	228	WP_162682830.1	toxin-antitoxin system, antitoxin component	Antitoxin
GZH82_RS13050	2736694..2738151	-	1458	WP_162682831.1	glutamate synthase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-85)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10724.62 Da
• Isoelectric Point: 10.5831

>T148942 WP_162682829.1 NZ_CP048279:c2735979-2735707 [Staphylococcus sp. MI 10-1553]
MKYSLKISEKTNKKLGKMDKPTRTFLLKWLYHHVHHSENPRLHGIALQGELSHLWRYRIGKYRAIVEIQDDELVVLTIDI
GLRASIYKRK

Nucleotide

• Length: 273 bp

>T148942 NZ_CP063906:3425817-3426350 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8728.85 Da
• Isoelectric Point: 4.0158

>AT148942 WP_162682830.1 NZ_CP048279:c2736203-2735976 [Staphylococcus sp. MI 10-1553]
MATITIRVSDDEKVFLKYMADFLGLSLSEVLKQYTFEDLEDIYDAKVGDEALKEYRETGQNALDIEDVMKQWDVK

Nucleotide

• Length: 228 bp

>AT148942 NZ_CP063906:3425540-3425806 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA