Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1974862..1975383 Replicon chromosome
Accession NZ_CP048279
Organism Staphylococcus sp. MI 10-1553

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag GZH82_RS09170 Protein ID WP_162682241.1
Coordinates 1974862..1975083 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag GZH82_RS09175 Protein ID WP_086429166.1
Coordinates 1975096..1975383 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH82_RS09155 1970541..1971296 - 756 WP_162683035.1 peptidase -
GZH82_RS13955 1972139..1972285 - 147 WP_014613367.1 hypothetical protein -
GZH82_RS09160 1972371..1974551 - 2181 WP_162682239.1 heavy metal translocating P-type ATPase -
GZH82_RS09165 1974637..1974858 - 222 WP_162682240.1 cation transporter -
GZH82_RS09170 1974862..1975083 - 222 WP_162682241.1 heavy-metal-associated domain-containing protein Toxin
GZH82_RS09175 1975096..1975383 - 288 WP_086429166.1 copper-sensing transcriptional repressor CsoR Antitoxin
GZH82_RS09180 1975515..1977005 + 1491 WP_162682242.1 cardiolipin synthase -
GZH82_RS09185 1977027..1977683 + 657 WP_162682243.1 HD domain-containing protein -
GZH82_RS09190 1977729..1978595 - 867 WP_162682244.1 membrane protein insertase YidC -
GZH82_RS09195 1978684..1979322 - 639 WP_096556492.1 thiamine phosphate synthase -
GZH82_RS09200 1979312..1980115 - 804 WP_162682245.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8222.22 Da        Isoelectric Point: 4.1258

>T148941 WP_162682241.1 NZ_CP048279:c1975083-1974862 [Staphylococcus sp. MI 10-1553]
MENGYVKVTQLTTEEQQQQLSDRLLRLIGVESVDIDLTTQQIALTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T148941 NZ_CP063906:3390254-3390568 [Klebsiella pneumoniae]
ATTTCAACTGTACCGGCCAAGGTGCCGGTTTCGTCACGTCCGTCGCCCGTGCAGGTCTGGCAGCAACTTTTAACGTATCT
GCTGGATCACCATTACGGCCTGACGCTTAACGACACACCATTCCATGACGACGGGGCCATCGAGGAGCATATCGATGCAG
GAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGCATCGACCGCAAAGGGTTTAGCTGG
CAGGAACAGACTCCGTTCCTGACCGCGACTGATATTCTCCGAGCCAGGCGAGCTACCGGATTAACAAATACTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11072.68 Da        Isoelectric Point: 6.4862

>AT148941 WP_086429166.1 NZ_CP048279:c1975383-1975096 [Staphylococcus sp. MI 10-1553]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIMHKIEEGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT148941 NZ_CP063906:3389888-3390211 [Klebsiella pneumoniae]
ATGTCAATCACACCACCTCATGAATGGGGTCTACAAAGCGATATCACCCCTCGATTTGCCGCAAGATTAGTTCAGGAAGG
CAACCGGCTGTATTACCTGGCTGACAGGGCTGGATTGACGGGGAGTTTTAGTCCAATGCACCTGCAGAAATTAGATCTGG
CTTTCCCGCTGTTTGTCGAACAACTGGAAGATATGCTGTGTGCTGGCGAACTAAATCCACATCAGCAACGTCAGGTGAAA
ATTCAACTTGCGAGTTTAACCTGTATAGCTGATACCCTTGGTAGCTGCGGTTACGTTTACATTTCTATTTATCCCACACC
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References