Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 304631..305112 Replicon chromosome
Accession NZ_CP048279
Organism Staphylococcus sp. MI 10-1553

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GZH82_RS01300 Protein ID WP_162682971.1
Coordinates 304631..304894 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GZH82_RS01305 Protein ID WP_162680966.1
Coordinates 304891..305112 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH82_RS01280 301012..302169 + 1158 WP_162680963.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
GZH82_RS01285 302334..303476 - 1143 WP_162680964.1 IS200/IS605 family element transposase accessory protein TnpB -
GZH82_RS01290 303492..303896 - 405 WP_162680965.1 IS200/IS605 family transposase -
GZH82_RS01295 304091..304546 + 456 Protein_255 ATPase -
GZH82_RS01300 304631..304894 - 264 WP_162682971.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZH82_RS01305 304891..305112 - 222 WP_162680966.1 CopG family transcriptional regulator Antitoxin
GZH82_RS01310 305318..305707 + 390 WP_203232828.1 hypothetical protein -
GZH82_RS01315 305960..306268 + 309 Protein_259 DNA topology modulation protein FlaR -
GZH82_RS01320 306429..307538 + 1110 WP_162680967.1 NAD(P)-binding domain-containing protein -
GZH82_RS01325 307532..308866 + 1335 WP_162680968.1 ferrous iron transporter B -
GZH82_RS01330 309022..310071 + 1050 WP_162680969.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Protein of unknown function DUF6290

(1-68)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10257.97 Da        Isoelectric Point: 10.1333

>T148939 WP_162682971.1 NZ_CP048279:c304894-304631 [Staphylococcus sp. MI 10-1553]
MMYTLQYSDKVLKQLSKLDKGRQKLILTWIANNLENCENPRIKGKGLTANRSREWRYRVGDYRIICDIQDSELIILALSI
GHRKSIY

Download         Length: 264 bp

>T148939 NZ_CP063906:3154758-3155633 [Klebsiella pneumoniae]
ATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATTTGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGA
TTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAGGCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAG
ATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAAGATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACC
ACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAG
GAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTATTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCC
TCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCCTGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.65 Da        Isoelectric Point: 4.5637

>AT148939 WP_162680966.1 NZ_CP048279:c305112-304891 [Staphylococcus sp. MI 10-1553]
MAISVRLNTQDEQLFKSYAKTNNMTLSELFRNAVFEKIEGEYDLAVYRESLEEYNKNPVIYSHAEVCRLLGIE

Download         Length: 222 bp

>AT148939 NZ_CP063906:3153952-3154710 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References