Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3762727..3763544 Replicon chromosome
Accession NZ_CP048275
Organism Morganella morganii strain N18-00103

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag GYM50_RS18095 Protein ID WP_004236532.1
Coordinates 3762727..3763209 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag GYM50_RS18100 Protein ID WP_004236533.1
Coordinates 3763236..3763544 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYM50_RS18065 3758086..3758709 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
GYM50_RS18070 3758728..3759723 - 996 WP_004236526.1 serine/threonine protein kinase -
GYM50_RS18075 3759723..3759992 - 270 WP_004240741.1 YihD family protein -
GYM50_RS18080 3760195..3761310 + 1116 WP_087825438.1 molybdenum cofactor guanylyltransferase MobA -
GYM50_RS18085 3761525..3761827 + 303 WP_004240743.1 exported protein precursor -
GYM50_RS18090 3761955..3762476 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
GYM50_RS19040 3762473..3762613 + 141 WP_004236531.1 hypothetical protein -
GYM50_RS18095 3762727..3763209 - 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
GYM50_RS18100 3763236..3763544 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
GYM50_RS18105 3763676..3765028 - 1353 WP_046024838.1 glutathione-disulfide reductase -
GYM50_RS18110 3765098..3765940 - 843 WP_036417394.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
GYM50_RS18115 3766130..3766519 + 390 WP_004236536.1 DUF1090 domain-containing protein -
GYM50_RS18120 3766931..3767923 + 993 WP_087825439.1 inner membrane protein YhjD -
GYM50_RS18125 3768031..3768237 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T148938 WP_004236532.1 NZ_CP048275:c3763209-3762727 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

>T148938 NZ_CP063906:2837382-2837765 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT148938 WP_004236533.1 NZ_CP048275:c3763544-3763236 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT148938 NZ_CP063906:2837140-2837382 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References