148934

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1763571..1764483 Replicon chromosome
Accession NZ_CP048273
Organism Bacillus sp. NSP9.1

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7FAV9
Locus tag M654_RS09185 Protein ID WP_026586617.1
Coordinates 1763737..1764483 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7F9D9
Locus tag M654_RS09180 Protein ID WP_026586616.1
Coordinates 1763571..1763735 (-) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M654_RS09155 1758816..1759913 + 1098 WP_026586613.1 mannonate dehydratase -
M654_RS09160 1759889..1760737 + 849 WP_026588403.1 SDR family oxidoreductase -
M654_RS09165 1760759..1761772 + 1014 WP_026586614.1 zinc-binding alcohol dehydrogenase family protein -
M654_RS09170 1761826..1763097 + 1272 WP_026586615.1 MFS transporter -
M654_RS09175 1763114..1763494 + 381 WP_163170555.1 hypothetical protein -
M654_RS09180 1763571..1763735 - 165 WP_026586616.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M654_RS09185 1763737..1764483 - 747 WP_026586617.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M654_RS09190 1764593..1765591 - 999 WP_026586618.1 inorganic phosphate transporter -
M654_RS09195 1765604..1766221 - 618 WP_026586619.1 DUF47 domain-containing protein -
M654_RS09200 1766554..1768305 + 1752 WP_026586620.1 gamma-glutamyltransferase -
M654_RS09205 1768441..1769085 + 645 WP_026586621.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-54)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29298.67 Da        Isoelectric Point: 4.6449

>T148934 WP_026586617.1 NZ_CP048273:c1764483-1763737 [Bacillus sp. NSP9.1]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTYQYLLKNEPIHIYYGSIEAYAEGIEKLISRFGEKMNISAAL
CEYNSNESKDHLLEHMENRFAVQEKLDRKDVYYEENGKMVLIPFSIHDYDYVMKLTSEDLVTEFDYLLFTSLTSVYDLLL
PNEEEGDD

Download         Length: 747 bp

>T148934 NZ_CP063906:c1008236-1007904 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6505.61 Da        Isoelectric Point: 10.9064

>AT148934 WP_026586616.1 NZ_CP048273:c1763735-1763571 [Bacillus sp. NSP9.1]
MEPAFQENAKKRLSFKMFKKQSKTSIAKYEVSPHTERIFKQNERLIGEYKRKKA

Download         Length: 165 bp

>AT148934 NZ_CP063906:c1008494-1008237 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FAV9

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7F9D9

References