Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3174708..3175278 Replicon chromosome
Accession NZ_CP048261
Organism Streptomyces rimosus subsp. rimosus ATCC 10970

Toxin (Protein)


Gene name mazF Uniprot ID L8ERH5
Locus tag SRIM_RS14155 Protein ID WP_003982453.1
Coordinates 3174708..3175055 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID L8ERT3
Locus tag SRIM_RS14160 Protein ID WP_003982452.1
Coordinates 3175042..3175278 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRIM_RS14145 3173004..3174035 + 1032 WP_003982455.1 aspartate-semialdehyde dehydrogenase -
SRIM_RS14150 3174106..3174627 - 522 WP_003982454.1 DUF1203 domain-containing protein -
SRIM_RS14155 3174708..3175055 - 348 WP_003982453.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SRIM_RS14160 3175042..3175278 - 237 WP_003982452.1 ribbon-helix-helix domain-containing protein Antitoxin
SRIM_RS14165 3175318..3175917 - 600 WP_003982451.1 Uma2 family endonuclease -
SRIM_RS14170 3176051..3178627 + 2577 WP_003982450.1 aminopeptidase N -
SRIM_RS14175 3178699..3179856 - 1158 WP_003982449.1 allantoicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12493.43 Da        Isoelectric Point: 10.8691

>T148932 WP_003982453.1 NZ_CP048261:c3175055-3174708 [Streptomyces rimosus subsp. rimosus ATCC 10970]
MRRGDLYLVDLEPVRGSEANKYRPAVVVSNDAANRSVQRAGRGVVTVVPVTANVARVYPFQVLLTADDCGLPRDSKAQCE
QVRAVSVERLGRRVGSVPARVMVGLDAALRRHLAL

Download         Length: 348 bp

>T148932 NZ_CP063906:c863600-863498 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8374.07 Da        Isoelectric Point: 3.7856

>AT148932 WP_003982452.1 NZ_CP048261:c3175278-3175042 [Streptomyces rimosus subsp. rimosus ATCC 10970]
MKISVSLPEEDIAFLDAYGKKTDADSRSAVIHAAVELLRASELEADYASAWEEWDESDDALLWDGVSGDGIGSADAAR

Download         Length: 237 bp

>AT148932 NZ_CP063906:863491-863636 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L8ERH5

Antitoxin

Source ID Structure
AlphaFold DB L8ERT3

References