Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 606..41404 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP048255 | ||
| Organism | Neisseria gonorrhoeae strain CT530 | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | D5K9G7 |
| Locus tag | GYN04_RS11390 | Protein ID | WP_003701905.1 |
| Coordinates | 41404..606 (+) | Length | -13599 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | GYN04_RS11395 | Protein ID | WP_003701903.1 |
| Coordinates | 621..1052 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GYN04_RS11395 (GYN04_11090) | 621..1052 | + | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| GYN04_RS11400 (GYN04_11095) | 1104..1658 | + | 555 | WP_003701901.1 | recombinase family protein | - |
| GYN04_RS11405 (GYN04_11100) | 1768..2058 | - | 291 | WP_003701899.1 | virulence factor | - |
| GYN04_RS11410 (GYN04_11105) | 2161..2760 | - | 600 | WP_003701898.1 | TrbN protein | - |
| GYN04_RS11415 (GYN04_11110) | 2760..3332 | - | 573 | WP_014580059.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| GYN04_RS11420 (GYN04_11115) | 3325..4932 | - | 1608 | WP_228547153.1 | P-type conjugative transfer protein TrbL | - |
| GYN04_RS11425 (GYN04_11120) | 5167..5943 | - | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
| GYN04_RS11430 (GYN04_11125) | 5956..7395 | - | 1440 | WP_003701889.1 | TrbI/VirB10 family protein | - |
| GYN04_RS11435 (GYN04_11130) | 7399..7809 | - | 411 | WP_003701887.1 | TrbH protein | - |
| GYN04_RS11440 (GYN04_11135) | 7806..8672 | - | 867 | WP_003701885.1 | P-type conjugative transfer protein TrbG | - |
| GYN04_RS11445 (GYN04_11140) | 8685..9392 | - | 708 | WP_003701883.1 | VirB8/TrbF family protein | - |
| GYN04_RS11450 (GYN04_11145) | 9392..11956 | - | 2565 | WP_003701881.1 | VirB4 family type IV secretion/conjugal transfer ATPase | - |
| GYN04_RS11455 (GYN04_11150) | 11953..12270 | - | 318 | WP_013085581.1 | conjugal transfer protein TrbD | - |
| GYN04_RS11460 (GYN04_11155) | 12275..12658 | - | 384 | WP_003701877.1 | conjugal transfer system pilin TrbC | - |
| GYN04_RS11465 (GYN04_11160) | 12760..13758 | - | 999 | WP_003701874.1 | P-type conjugative transfer ATPase TrbB | - |
| GYN04_RS11470 (GYN04_11165) | 13886..14251 | - | 366 | WP_003701872.1 | transcriptional regulator | - |
| GYN04_RS11475 (GYN04_11170) | 14311..14694 | + | 384 | WP_003701870.1 | single-stranded DNA-binding protein | - |
| GYN04_RS11480 (GYN04_11175) | 14698..15576 | + | 879 | WP_003701868.1 | plasmid replication initiator TrfA | - |
| GYN04_RS11485 (GYN04_11180) | 16194..16541 | + | 348 | WP_003701866.1 | hypothetical protein | - |
| GYN04_RS11490 (GYN04_11185) | 16622..16867 | + | 246 | WP_003701863.1 | hypothetical protein | - |
| GYN04_RS11495 (GYN04_11190) | 16877..17632 | + | 756 | WP_003701861.1 | ParA family protein | - |
| GYN04_RS11500 (GYN04_11195) | 17638..18555 | + | 918 | WP_003701858.1 | ParB/RepB/Spo0J family partition protein | - |
| GYN04_RS11505 (GYN04_11200) | 18762..19118 | + | 357 | WP_003701856.1 | hypothetical protein | - |
| GYN04_RS11510 (GYN04_11205) | 19155..19691 | + | 537 | WP_003701854.1 | hypothetical protein | - |
| GYN04_RS11515 (GYN04_11210) | 19748..20230 | - | 483 | WP_003701852.1 | hypothetical protein | - |
| GYN04_RS11520 (GYN04_11215) | 20238..20963 | - | 726 | WP_003701851.1 | conjugal transfer protein TraL | - |
| GYN04_RS11525 | 20964..21665 | - | 702 | WP_226888040.1 | TraK family protein | - |
| GYN04_RS11530 (GYN04_11225) | 21715..22092 | + | 378 | WP_050164974.1 | conjugal transfer protein TraJ | - |
| GYN04_RS11535 (GYN04_11230) | 22095..24488 | + | 2394 | WP_003701842.1 | relaxase | - |
| GYN04_RS11540 (GYN04_11235) | 24505..26394 | + | 1890 | WP_003701841.1 | type IV secretory system conjugative DNA transfer family protein | - |
| GYN04_RS11545 (GYN04_11240) | 26391..26927 | + | 537 | WP_003701840.1 | conjugative transfer signal peptidase TraF | - |
| GYN04_RS11550 (GYN04_11245) | 26930..29125 | + | 2196 | WP_013085583.1 | DNA topoisomerase 3 | - |
| GYN04_RS11555 (GYN04_11255) | 29314..32313 | + | 3000 | WP_014580052.1 | DUF5710 domain-containing protein | - |
| GYN04_RS11560 (GYN04_11260) | 32346..32816 | + | 471 | WP_228547154.1 | transcription elongation factor | - |
| GYN04_RS11565 | 32813..32865 | + | 53 | Protein_35 | twin-arginine translocation signal domain-containing protein | - |
| GYN04_RS11570 (GYN04_11265) | 32939..33373 | + | 435 | WP_229505493.1 | DUF882 domain-containing protein | - |
| GYN04_RS11575 (GYN04_11270) | 33370..33729 | + | 360 | WP_003701922.1 | hypothetical protein | - |
| GYN04_RS11580 (GYN04_11275) | 34096..34410 | + | 315 | WP_082295984.1 | hypothetical protein | - |
| GYN04_RS11585 (GYN04_11280) | 34424..34765 | + | 342 | WP_013085576.1 | hypothetical protein | - |
| GYN04_RS11590 (GYN04_11285) | 34769..35665 | + | 897 | WP_003701917.1 | hypothetical protein | - |
| GYN04_RS11595 (GYN04_11290) | 35817..36290 | - | 474 | WP_013085577.1 | hypothetical protein | - |
| GYN04_RS11600 (GYN04_11295) | 36382..38301 | - | 1920 | WP_025456273.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| GYN04_RS11605 (GYN04_11300) | 38317..38433 | - | 117 | WP_001791010.1 | tetracycline resistance determinant leader peptide | - |
| GYN04_RS11610 (GYN04_11305) | 38821..39342 | + | 522 | WP_003701911.1 | hypothetical protein | - |
| GYN04_RS11615 (GYN04_11310) | 39719..39973 | + | 255 | WP_013085578.1 | hypothetical protein | - |
| GYN04_RS11620 (GYN04_11315) | 39970..41178 | + | 1209 | WP_003701908.1 | zeta toxin family protein | - |
| GYN04_RS11625 (GYN04_11320) | 41212..41397 | + | 186 | WP_003701907.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) | - | 1..42003 | 42003 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: -13599 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T148930 WP_003701905.1 NZ_CP048255:41404-606 [Neisseria gonorrhoeae]
Download Length: -40797 bp
>T148930 NZ_CP063905:210287-210730 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT148930 WP_003701903.1 NZ_CP048255:621-1052 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
>AT148930 NZ_CP063905:210060-210290 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|