Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 889405..890060 Replicon chromosome
Accession NZ_CP048250
Organism Neisseria gonorrhoeae strain CT532

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag GYN05_RS04580 Protein ID WP_003691083.1
Coordinates 889405..889824 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag GYN05_RS04585 Protein ID WP_003688410.1
Coordinates 889824..890060 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYN05_RS04560 (GYN05_04420) 884639..886180 - 1542 WP_003697015.1 MDR family MFS transporter -
GYN05_RS04565 (GYN05_04425) 886328..887107 + 780 WP_003701284.1 (Fe-S)-binding protein -
GYN05_RS04570 (GYN05_04430) 887104..887805 + 702 WP_003688414.1 lactate utilization protein C -
GYN05_RS04575 (GYN05_04435) 887802..889256 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
GYN05_RS04580 (GYN05_04440) 889405..889824 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
GYN05_RS04585 (GYN05_04445) 889824..890060 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
GYN05_RS04590 (GYN05_04455) 890508..891086 - 579 WP_003688041.1 IS3 family transposase -
GYN05_RS04595 (GYN05_04460) 891091..891492 - 402 WP_020996834.1 helix-turn-helix domain-containing protein -
GYN05_RS04600 (GYN05_04465) 891731..892117 + 387 Protein_912 IS110 family transposase -
GYN05_RS04605 (GYN05_04470) 892500..893390 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
GYN05_RS04610 (GYN05_04475) 893401..894567 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
GYN05_RS04615 (GYN05_04480) 894639..894926 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T148924 WP_003691083.1 NZ_CP048250:c889824-889405 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T148924 NZ_CP063904:c3500239-3499955 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT148924 WP_003688410.1 NZ_CP048250:c890060-889824 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT148924 NZ_CP063904:c3500471-3500229 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References