Detailed information of TA system TA148923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1581937..1582622
• Replicon: chromosome
• Accession: NZ_CP048246
• Organism: Neisseria gonorrhoeae strain CT602

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: GYN06_RS08170
• Protein ID: WP_003689143.1
• Coordinates: 1582440..1582622 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: GYN06_RS08165
• Protein ID: WP_003691454.1
• Coordinates: 1581937..1582338 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYN06_RS08110 (GYN06_07910)	1576982..1577197	-	216	WP_003691538.1	hypothetical protein	-
GYN06_RS08115 (GYN06_07915)	1577249..1577740	-	492	WP_003691537.1	siphovirus Gp157 family protein	-
GYN06_RS08120 (GYN06_07920)	1577737..1577919	-	183	WP_003691535.1	hypothetical protein	-
GYN06_RS08125 (GYN06_07925)	1578059..1578745	-	687	WP_003691532.1	hypothetical protein	-
GYN06_RS08130	1578814..1578975	-	162	WP_003691530.1	hypothetical protein	-
GYN06_RS08135 (GYN06_07930)	1578972..1579247	-	276	WP_003703838.1	hypothetical protein	-
GYN06_RS08140 (GYN06_07935)	1579400..1579732	-	333	WP_003696914.1	hypothetical protein	-
GYN06_RS08145 (GYN06_07940)	1579873..1580160	-	288	WP_123768272.1	hypothetical protein	-
GYN06_RS08150 (GYN06_07945)	1580157..1580633	-	477	WP_002255718.1	hypothetical protein	-
GYN06_RS08155 (GYN06_07950)	1580666..1580866	-	201	WP_003704298.1	hypothetical protein	-
GYN06_RS08160 (GYN06_07955)	1581077..1581838	+	762	WP_012503753.1	hypothetical protein	-
GYN06_RS08165 (GYN06_07960)	1581937..1582338	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GYN06_RS08170 (GYN06_07965)	1582440..1582622	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
GYN06_RS08175 (GYN06_07970)	1582792..1583610	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
GYN06_RS08180 (GYN06_07975)	1583607..1584305	-	699	WP_003689139.1	hypothetical protein	-
GYN06_RS08185 (GYN06_07980)	1584544..1585254	-	711	WP_050161643.1	helix-turn-helix transcriptional regulator	-
GYN06_RS08190 (GYN06_07985)	1585370..1585558	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
GYN06_RS08195	1585638..1585793	+	156	WP_003691446.1	hypothetical protein	-
GYN06_RS08200 (GYN06_07990)	1585770..1585958	-	189	WP_003706568.1	hypothetical protein	-
GYN06_RS08205 (GYN06_07995)	1586131..1586358	+	228	WP_003691442.1	helix-turn-helix domain-containing protein	-
GYN06_RS08210 (GYN06_08000)	1586355..1587380	+	1026	WP_250328371.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1566754..1600272	33518

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T148923 WP_003689143.1 NZ_CP048246:c1582622-1582440 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T148923 NZ_CP063904:3437800-3438735 [Klebsiella pneumoniae]
CTGCTTTTTTCTGATGTAACAGATGCTCTTGGTATTGAGTCCGGCGCTATTGTAGAAAAAGATCACTATATCGTTGAGCT
TTTACATTTACTGAAACCGCTAACATTTGACACTCATCAATTGCTGTTTGCCGGAGGAACTGCACTGGCAAAATCGGGCA
TTGTGCTTAACCGAATGTCGGAAGATGTAGATATAAAACTGGTACCCACAGATACTTTCTTGTCTCTTTCGCGCACCCAG
CGCAAAGGTATTCGTAAAGAGATCGTCCAGACAATTTCTCATGCAATAACTGCAACAGACATGTTCAGCTTTGACGATGC
CCATCCAAAAGTGACGCGGGATGAATATCGTTACAACGACATACCCGTTCGCTATCCGCAGCGGGTAGCGCAAGCACCTT
GCCTGCGTCCTTTTATCCAGTTGGAATTGATGGAAGCAAATTTGCTTGAGGCACCAGAGTTCAGGGATATTCATACACTG
GTGACGACACTTACTGGAAAAGCACCTGTCATTTCAGCCTTCCCCTGCGCCACAATTATCAGTACTCAGGCAGAAAAACT
GGTGGCTATGCTGCGCCGTACTGCAGCAGTTGCGCGTAATATTGAACGCCAGGATGACGCTTCGCTGGTACGTCATATCT
ACGACACATATTGTATCGTGCAGGCAGGCAATGTTGATATGTGTTTGCTTACTGATTTTTTTAAGCAAACCATTGAGCAA
GATATCCAGCGTTATGGCAATCAGTATCCGCAGTTTTGTGTTTCACCAAATGATGAGCTAAAAATGGGGCTGGACGAACT
TGAGCATAACCCGCTTTATAAGACACGCTACCAGCAATTTGTTGCCCCAATGGTATATGGTGCTCGCAAGGTATCGTGGG
ATGAAGCGTATGCTTCCTTTCGTCAAATGGCGTTAATAATTCTAGATACTTACTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT148923 WP_003691454.1 NZ_CP048246:c1582338-1581937 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT148923 NZ_CP063904:3437398-3437793 [Klebsiella pneumoniae]
ATGACGATAAAAACACGCATTCAGTCACGACTGAAACGCTCAAAACGCTATGTATTCACTCGTGACGATTTCAAGGATAT
TGCAGGCTATGATCAGATTGGCAGGGTATTGCGCGACCTTCTCAAAGAGGGGCAACTACTGAAGGTGGGCTACGGTGTGT
ACACCAAAGCGCGTCGGAACAGCATTACTGGAAAAGTCATGCCCGCAGCACCAAGGGGATCTTCGGCAGTGATCGTTGAA
ACGCTGGAGCGCCTGAAAGTACGTTACCGCTATGAAGGAGCTACACAGACATATAATAGTGGCGAATCCACGCAAATCCC
CGTGTCACCGGAGATCAAAACATCTCCGCGCTTTAAACGCGCGTTGTCTGTGGGGAACAGCAAACTAAATGGATAA

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2