Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 891749..892404 Replicon chromosome
Accession NZ_CP048246
Organism Neisseria gonorrhoeae strain CT602

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag GYN06_RS04595 Protein ID WP_003691083.1
Coordinates 891749..892168 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag GYN06_RS04600 Protein ID WP_003688410.1
Coordinates 892168..892404 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYN06_RS04575 (GYN06_04450) 886983..888524 - 1542 WP_003701286.1 MDR family MFS transporter -
GYN06_RS04580 (GYN06_04455) 888672..889451 + 780 WP_003688416.1 (Fe-S)-binding protein -
GYN06_RS04585 (GYN06_04460) 889448..890149 + 702 WP_003688414.1 lactate utilization protein C -
GYN06_RS04590 (GYN06_04465) 890146..891600 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
GYN06_RS04595 (GYN06_04470) 891749..892168 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
GYN06_RS04600 (GYN06_04475) 892168..892404 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
GYN06_RS04605 (GYN06_04485) 892852..893430 - 579 WP_003688041.1 IS3 family transposase -
GYN06_RS04610 (GYN06_04490) 893435..893836 - 402 WP_020997339.1 helix-turn-helix domain-containing protein -
GYN06_RS04615 (GYN06_04495) 894075..894461 + 387 Protein_915 IS110 family transposase -
GYN06_RS04620 (GYN06_04500) 894844..895734 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
GYN06_RS04625 (GYN06_04505) 895745..896911 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
GYN06_RS04630 (GYN06_04510) 896983..897270 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-124)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T148922 WP_003691083.1 NZ_CP048246:c892168-891749 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T148922 NZ_CP063904:c3383861-3383328 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT148922 WP_003688410.1 NZ_CP048246:c892404-892168 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT148922 NZ_CP063904:c3384138-3383872 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O


Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References