Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 62112..62694 | Replicon | chromosome |
Accession | NZ_CP048243 | ||
Organism | Ewingella americana strain B6-1 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | - |
Locus tag | GXP68_RS00310 | Protein ID | WP_185688981.1 |
Coordinates | 62359..62694 (+) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | - |
Locus tag | GXP68_RS00305 | Protein ID | WP_154145766.1 |
Coordinates | 62112..62357 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GXP68_RS00265 | 57347..57823 | - | 477 | WP_034794202.1 | GNAT family N-acetyltransferase | - |
GXP68_RS00270 | 57829..58368 | - | 540 | WP_185690098.1 | hypothetical protein | - |
GXP68_RS00275 | 58583..59215 | + | 633 | WP_185688976.1 | glutathione transferase | - |
GXP68_RS00280 | 59276..59722 | - | 447 | WP_185688977.1 | GNAT family N-acetyltransferase | - |
GXP68_RS00285 | 59737..60369 | - | 633 | WP_185688978.1 | LysE family translocator | - |
GXP68_RS00290 | 60374..60829 | - | 456 | WP_185688979.1 | GNAT family N-acetyltransferase | - |
GXP68_RS00295 | 61026..61283 | - | 258 | WP_034794197.1 | DUF1471 domain-containing protein | - |
GXP68_RS00300 | 61692..61940 | + | 249 | WP_185688980.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
GXP68_RS00305 | 62112..62357 | + | 246 | WP_154145766.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
GXP68_RS00310 | 62359..62694 | + | 336 | WP_185688981.1 | endoribonuclease MazF | Toxin |
GXP68_RS00315 | 62752..63149 | - | 398 | Protein_62 | hypothetical protein | - |
GXP68_RS00320 | 63221..63919 | - | 699 | WP_185688982.1 | urea ABC transporter ATP-binding subunit UrtE | - |
GXP68_RS00325 | 63935..64741 | - | 807 | WP_185688983.1 | urea ABC transporter ATP-binding protein UrtD | - |
GXP68_RS00330 | 64738..65814 | - | 1077 | WP_185688984.1 | urea ABC transporter permease subunit UrtC | - |
GXP68_RS00335 | 65814..67376 | - | 1563 | WP_202034364.1 | urea ABC transporter permease subunit UrtB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12136.17 Da Isoelectric Point: 8.5104
>T148902 WP_185688981.1 NZ_CP048243:62359-62694 [Ewingella americana]
MVKPSIPDAGDIIWLDFDPQAGHEQAGHRPAVVLSPAAYNDRVGLLLCCPMTTKIKGYPFEVLIAGIRQSAVLSDQIKSL
DWRKRNAVKKGTVSLLELDEVRAKVKALIDG
MVKPSIPDAGDIIWLDFDPQAGHEQAGHRPAVVLSPAAYNDRVGLLLCCPMTTKIKGYPFEVLIAGIRQSAVLSDQIKSL
DWRKRNAVKKGTVSLLELDEVRAKVKALIDG
Download Length: 336 bp
>T148902 NZ_CP063900:563666-564988 [Klebsiella quasipneumoniae]
ATGGCGACGCTCACCACCTGGATGAACAATGCGCGCGTGGGAACCTTAACCCGCCAGGCCAACGGGGCGCACAGTTTCCG
CTATGATGAGGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGAGCGGATCGTCAGGCGCTATCAG
GCGCGTTCGAAACAGCCGTTCGATCTGCTGGCCGAGGTCGGGCGGGACAGCGTAGGGGCGGTGACTCTGCTGCCGCCGGG
GGAAGAGGCGCATCTTGCCGCGTTGCGCTGGCAGACGCTGGATGAGGCGCAGCTGACCGCTTTGCTGACCGCCTACCAGT
CGGATATTCCTCTCGGAATGGTGACCGGCCAGGACGATTTTCGTATCTCGGTGGCCGGCGCTCAGGAGAAAACCGCGCTG
CTGCGAATGGGCGAGCACTGGTGTATTCCGCAGGGCACCACCCCGACCACCCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAATATCTGTGCCTGGCGCTGGCCAGGGCGTTGG
GCCTGGCGGTGCCGGAGGCGGAGATTATCAACACGCCGCGGATCCGTGCGCTGGCGGTGACTCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGCGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCATTCGGCATACCGTCGTCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCCAGTGAGGCCCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTGTTCCAGTGGCTGACCGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGCGGCAGCTACCGGCTCACGCCGTTCTACGACATTATTTCGGCATTTCCGGTGCTGGGCGGGACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACGGAGATTAACGCTATCTATCCGCGTCATT
TTCTGGCGACCGCCAAAGCGGTTAACTTCCCCCGGGAGCAGATGCTGGCGATCCTGGGCGAGTTTGCCGACCGCGTGCCG
CAGGCCATCGAAAGCGCCCGCCAAACGCTGCCGTCGGACTTTTCCGCCCACGTCTGGCGGGCCATCACGGAGAACATGCT
GAAACTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGGGATAG
ATGGCGACGCTCACCACCTGGATGAACAATGCGCGCGTGGGAACCTTAACCCGCCAGGCCAACGGGGCGCACAGTTTCCG
CTATGATGAGGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGAGCGGATCGTCAGGCGCTATCAG
GCGCGTTCGAAACAGCCGTTCGATCTGCTGGCCGAGGTCGGGCGGGACAGCGTAGGGGCGGTGACTCTGCTGCCGCCGGG
GGAAGAGGCGCATCTTGCCGCGTTGCGCTGGCAGACGCTGGATGAGGCGCAGCTGACCGCTTTGCTGACCGCCTACCAGT
CGGATATTCCTCTCGGAATGGTGACCGGCCAGGACGATTTTCGTATCTCGGTGGCCGGCGCTCAGGAGAAAACCGCGCTG
CTGCGAATGGGCGAGCACTGGTGTATTCCGCAGGGCACCACCCCGACCACCCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAATATCTGTGCCTGGCGCTGGCCAGGGCGTTGG
GCCTGGCGGTGCCGGAGGCGGAGATTATCAACACGCCGCGGATCCGTGCGCTGGCGGTGACTCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGCGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCATTCGGCATACCGTCGTCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCCAGTGAGGCCCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTGTTCCAGTGGCTGACCGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGCGGCAGCTACCGGCTCACGCCGTTCTACGACATTATTTCGGCATTTCCGGTGCTGGGCGGGACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACGGAGATTAACGCTATCTATCCGCGTCATT
TTCTGGCGACCGCCAAAGCGGTTAACTTCCCCCGGGAGCAGATGCTGGCGATCCTGGGCGAGTTTGCCGACCGCGTGCCG
CAGGCCATCGAAAGCGCCCGCCAAACGCTGCCGTCGGACTTTTCCGCCCACGTCTGGCGGGCCATCACGGAGAACATGCT
GAAACTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGGGATAG
Antitoxin
Download Length: 82 a.a. Molecular weight: 8735.08 Da Isoelectric Point: 4.5183
>AT148902 WP_154145766.1 NZ_CP048243:62112-62357 [Ewingella americana]
MPQVIVKKWGNSPSVRLPVAIMEAASLKVDDTVEIAVEDGKIIIVPVRAKTYSLDSLLGGVTESNMHEEVDFGSPTGREV
L
MPQVIVKKWGNSPSVRLPVAIMEAASLKVDDTVEIAVEDGKIIIVPVRAKTYSLDSLLGGVTESNMHEEVDFGSPTGREV
L
Download Length: 246 bp
>AT148902 NZ_CP063900:563400-563666 [Klebsiella quasipneumoniae]
ATGAATTCCCCGCAGATATACAGTCCGGTTCAGCTGGCCAATTACCTGAAACTGCTGCGCCAGCAAAATCACTGGACTCA
GGAGGCGCTGGCCAGCCGGATCGGCATTAAACAGGCGACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACCCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAACCGGCAGAGACGGCGATGATTCCC
GATAACACCACGGATCTTGACTGGTAA
ATGAATTCCCCGCAGATATACAGTCCGGTTCAGCTGGCCAATTACCTGAAACTGCTGCGCCAGCAAAATCACTGGACTCA
GGAGGCGCTGGCCAGCCGGATCGGCATTAAACAGGCGACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACCCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAACCGGCAGAGACGGCGATGATTCCC
GATAACACCACGGATCTTGACTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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