Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5729185..5729819 Replicon chromosome
Accession NZ_CP048209
Organism Paenibacillus lycopersici strain 12200R-189

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GXP70_RS25195 Protein ID WP_125664969.1
Coordinates 5729185..5729535 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GXP70_RS25200 Protein ID WP_162359351.1
Coordinates 5729538..5729819 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXP70_RS25170 5724250..5725725 - 1476 WP_162359346.1 Flp pilus assembly complex ATPase component TadA -
GXP70_RS25175 5725722..5726588 - 867 WP_162359347.1 hypothetical protein -
GXP70_RS25180 5726585..5727313 - 729 WP_162359348.1 SAF domain-containing protein -
GXP70_RS25185 5727506..5728180 - 675 WP_162359349.1 hypothetical protein -
GXP70_RS25190 5728204..5728893 - 690 WP_162359350.1 polymer-forming cytoskeletal protein -
GXP70_RS25195 5729185..5729535 - 351 WP_125664969.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GXP70_RS25200 5729538..5729819 - 282 WP_162359351.1 ribbon-helix-helix protein, CopG family Antitoxin
GXP70_RS25205 5730229..5731422 - 1194 WP_162359352.1 alanine racemase -
GXP70_RS25210 5731645..5732991 - 1347 WP_162359353.1 outer membrane lipoprotein-sorting protein -
GXP70_RS25215 5733220..5733591 + 372 WP_162359354.1 GNAT family N-acetyltransferase -
GXP70_RS25220 5733773..5734639 - 867 WP_162359355.1 PHP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12806.72 Da        Isoelectric Point: 5.1284

>T148899 WP_125664969.1 NZ_CP048209:c5729535-5729185 [Paenibacillus lycopersici]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAASHGFDRDSVLLLEQI
RTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF

Download         Length: 351 bp

>T148899 NZ_CP063898:c5466794-5466519 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCACCACACGCTGGAGCAACTGTTTAAAATCCCTGTGCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10621.23 Da        Isoelectric Point: 7.0150

>AT148899 WP_162359351.1 NZ_CP048209:c5729819-5729538 [Paenibacillus lycopersici]
VANLQNTKRIMISLPDHLLEEVDGIVARENSNRSEFIRQAMKLYLIERKKRQIRDSMQRGYLEMAKINLVMASEAFQAEE
DAGDTLGRLVSGV

Download         Length: 282 bp

>AT148899 NZ_CP063898:c5466522-5466163 [Klebsiella variicola]
ATGATCAAACCTAAAACGCCAAACTCAATGGAGATTGCCGGCCAGCCTGCCGTTATCAATTACGTGCCTGAGCTCAATGC
ATTCCGCGGTAAGTTCCTTGGATTATCAGGATATTGCGATTTTGTTTCCGATAGTATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAGTATCTCGCAGATTGTCATGAAGCGGGGATTGAGCCTTATGCTCACCCGGAAAAGATGAAAACC
TTCACGCTGCGCTATCCTGAGTCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCAGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References