Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3580682..3581335 Replicon chromosome
Accession NZ_CP048131
Organism Acinetobacter baumannii strain D46

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag KPZ59_RS17010 Protein ID WP_000607075.1
Coordinates 3580682..3581071 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KPZ59_RS17015 Protein ID WP_001288210.1
Coordinates 3581078..3581335 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPZ59_RS16995 (KPZ59_03411) 3575800..3577995 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
KPZ59_RS17000 (KPZ59_03412) 3578183..3578749 - 567 WP_000651539.1 rhombosortase -
KPZ59_RS17005 (KPZ59_03413) 3578827..3579912 - 1086 WP_000049106.1 hypothetical protein -
KPZ59_RS17010 (KPZ59_03415) 3580682..3581071 - 390 WP_000607075.1 membrane protein Toxin
KPZ59_RS17015 (KPZ59_03416) 3581078..3581335 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KPZ59_RS17020 (KPZ59_03417) 3581523..3582695 + 1173 WP_001190556.1 acyl-CoA dehydrogenase family protein -
KPZ59_RS17025 (KPZ59_03418) 3582744..3584234 - 1491 WP_000415123.1 NAD(P)/FAD-dependent oxidoreductase -
KPZ59_RS17030 (KPZ59_03419) 3584416..3584793 - 378 WP_001216380.1 50S ribosomal protein L17 -
KPZ59_RS17035 (KPZ59_03420) 3584812..3585819 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T148896 WP_000607075.1 NZ_CP048131:c3581071-3580682 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp

>T148896 NZ_CP063898:c3981272-3980940 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT148896 WP_001288210.1 NZ_CP048131:c3581335-3581078 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT148896 NZ_CP063898:c3981530-3981273 [Klebsiella variicola]
ATGTACAAAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAGCGCTGGAGCT
GTCGACAGACAGCGAAGTGGGTATGACTATAGATAATGGCTGCCTGATTATTGAACCGCAGAAACGGCCCCATTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9G864

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References