Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 5265444..5266036 Replicon chromosome
Accession NZ_CP048108
Organism Klebsiella michiganensis strain BD177

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GW952_RS24775 Protein ID WP_160741407.1
Coordinates 5265662..5266036 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GW952_RS24770 Protein ID WP_162122374.1
Coordinates 5265444..5265665 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW952_RS24750 5261004..5261558 + 555 WP_160741410.1 YgjV family protein -
GW952_RS24755 5261574..5262821 - 1248 WP_160741409.1 serine/threonine transporter SstT -
GW952_RS24760 5263076..5264044 - 969 WP_014839614.1 TerC family protein -
GW952_RS24765 5264295..5265284 - 990 WP_162122373.1 Gfo/Idh/MocA family oxidoreductase -
GW952_RS24770 5265444..5265665 + 222 WP_162122374.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GW952_RS24775 5265662..5266036 + 375 WP_160741407.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GW952_RS24780 5266016..5266519 - 504 WP_004105953.1 M48 family metallopeptidase -
GW952_RS24785 5266598..5268241 - 1644 WP_162122375.1 glycoside hydrolase family 43 protein -
GW952_RS24790 5268370..5269236 - 867 WP_160741405.1 AraC family transcriptional regulator -
GW952_RS24795 5269344..5270687 + 1344 WP_162122376.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13847.88 Da        Isoelectric Point: 6.0769

>T148882 WP_160741407.1 NZ_CP048108:5265662-5266036 [Klebsiella michiganensis]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIVNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T148882 NZ_CP063891:c115346-114876 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8171.16 Da        Isoelectric Point: 5.7996

>AT148882 WP_162122374.1 NZ_CP048108:5265444-5265665 [Klebsiella michiganensis]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALSDR

Download         Length: 222 bp

>AT148882 NZ_CP063891:c115786-115343 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References