Detailed information of TA system TA148881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 3341179..3341998
• Replicon: chromosome
• Accession: NZ_CP048108
• Organism: Klebsiella michiganensis strain BD177

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: GW952_RS15710
• Protein ID: WP_004110819.1
• Coordinates: 3341741..3341998 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: GW952_RS15705
• Protein ID: WP_202929147.1
• Coordinates: 3341179..3341625 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GW952_RS15690	3336554..3337951	+	1398	WP_160743290.1	MFS transporter	-
GW952_RS15695	3338070..3339410	+	1341	WP_162121973.1	carbohydrate porin	-
GW952_RS15700	3339533..3341161	-	1629	WP_160743319.1	SAM-dependent methyltransferase	-
GW952_RS15705	3341179..3341625	-	447	WP_202929147.1	N-acetyltransferase	Antitoxin
GW952_RS15710	3341741..3341998	-	258	WP_004110819.1	YjhX family toxin	Toxin
GW952_RS15715	3342674..3343858	+	1185	WP_014228054.1	mannonate dehydratase	-
GW952_RS15720	3343932..3345407	+	1476	WP_162121974.1	fructuronate reductase	-
GW952_RS15725	3345544..3346320	+	777	WP_160743294.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (14-95)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T148881 WP_004110819.1 NZ_CP048108:c3341998-3341741 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T148881 NZ_CP063891:c70698-70387 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16091.54 Da
• Isoelectric Point: 6.8990

>AT148881 WP_202929147.1 NZ_CP048108:c3341625-3341179 [Klebsiella michiganensis]
VADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMHILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQA
VFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQPISSQPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 447 bp

>AT148881 NZ_CP063891:c70390-69971 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2