Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2921499..2922105 Replicon chromosome
Accession NZ_CP048104
Organism Kroppenstedtia pulmonis strain W9323

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag GXN76_RS14005 Protein ID WP_173224113.1
Coordinates 2921499..2921849 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GXN76_RS14010 Protein ID WP_173225705.1
Coordinates 2921854..2922105 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXN76_RS13975 2916821..2918233 + 1413 WP_173224101.1 HAMP domain-containing protein -
GXN76_RS13980 2918339..2918479 - 141 WP_173224103.1 hypothetical protein -
GXN76_RS13985 2918611..2919396 - 786 WP_173224105.1 RNA polymerase sigma factor SigB -
GXN76_RS13990 2919362..2919853 - 492 WP_173224107.1 anti-sigma B factor RsbW -
GXN76_RS13995 2919871..2920191 - 321 WP_173224109.1 STAS domain-containing protein -
GXN76_RS14000 2920259..2921260 - 1002 WP_173224111.1 PP2C family protein-serine/threonine phosphatase -
GXN76_RS14005 2921499..2921849 - 351 WP_173224113.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GXN76_RS14010 2921854..2922105 - 252 WP_173225705.1 ribbon-helix-helix protein, CopG family Antitoxin
GXN76_RS14015 2922463..2923632 - 1170 WP_173225708.1 alanine racemase -
GXN76_RS14020 2923637..2924068 - 432 WP_173224115.1 hypothetical protein -
GXN76_RS14025 2924543..2925214 + 672 WP_173224117.1 hypothetical protein -
GXN76_RS14030 2925281..2926261 + 981 WP_173224119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12941.01 Da        Isoelectric Point: 6.7254

>T148838 WP_173224113.1 NZ_CP048104:c2921849-2921499 [Kroppenstedtia pulmonis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDHEMMVRVNEGLNISLGLIDF

Download         Length: 351 bp

>T148838 NZ_CP063881:c5121688-5120366 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGACTGCAGGCGCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9699.18 Da        Isoelectric Point: 4.6802

>AT148838 WP_173225705.1 NZ_CP048104:c2922105-2921854 [Kroppenstedtia pulmonis]
MISLPQNLLQEVDGLVEKEKSNRSEFVRQAMKLYLYERKKRLIREMMQQGYMEMAKINLNIASEAFEAEEEADDTTIRLV
SGV

Download         Length: 252 bp

>AT148838 NZ_CP063881:c5121954-5121688 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References