Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 324507..325114 Replicon chromosome
Accession NZ_CP048103
Organism Kroppenstedtia eburnea strain DSM 45196

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag GXN75_RS01835 Protein ID WP_009711015.1
Coordinates 324764..325114 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GXN75_RS01830 Protein ID WP_040388319.1
Coordinates 324507..324758 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXN75_RS01810 319796..321319 + 1524 WP_076525978.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
GXN75_RS01815 321394..322422 + 1029 WP_076526028.1 outer membrane lipoprotein carrier protein LolA -
GXN75_RS01820 322661..323101 + 441 WP_009711012.1 hypothetical protein -
GXN75_RS01825 323088..324332 + 1245 WP_076525976.1 alanine racemase -
GXN75_RS01830 324507..324758 + 252 WP_040388319.1 ribbon-helix-helix protein, CopG family Antitoxin
GXN75_RS01835 324764..325114 + 351 WP_009711015.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GXN75_RS01840 325304..326305 + 1002 WP_076525975.1 PP2C family protein-serine/threonine phosphatase -
GXN75_RS01845 326806..327126 + 321 WP_040387600.1 anti-sigma factor antagonist -
GXN75_RS01850 327141..327629 + 489 WP_009711018.1 anti-sigma B factor RsbW -
GXN75_RS01855 327592..328377 + 786 WP_076525973.1 RNA polymerase sigma factor SigB -
GXN75_RS01860 328434..329291 - 858 WP_076526026.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.05 Da        Isoelectric Point: 5.7048

>T148837 WP_009711015.1 NZ_CP048103:324764-325114 [Kroppenstedtia eburnea]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEIDARNYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMMRVNEALNISLGLIDF

Download         Length: 351 bp

>T148837 NZ_CP063881:4883010-4883327 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9675.14 Da        Isoelectric Point: 4.6538

>AT148837 WP_040388319.1 NZ_CP048103:324507-324758 [Kroppenstedtia eburnea]
MISLPQQLLQEVDGMVEKENSNRSEFVRQAMKLYLYERKKRLIREMMQQGYMEMAKINLNIASESFEAEEEADGTTIRLV
SGV

Download         Length: 252 bp

>AT148837 NZ_CP063881:4883403-4883699 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCCGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCAGCCAACCGGTGCAGCCAGAAAA
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References