Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 287176..287741 Replicon chromosome
Accession NZ_CP048103
Organism Kroppenstedtia eburnea strain DSM 45196

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GXN75_RS01670 Protein ID WP_009710973.1
Coordinates 287412..287741 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GXN75_RS01665 Protein ID WP_143457159.1
Coordinates 287176..287412 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXN75_RS01625 282287..282766 + 480 WP_076526014.1 SRPBCC family protein -
GXN75_RS01630 283359..283838 + 480 WP_159439730.1 SRPBCC family protein -
GXN75_RS01635 283997..284431 + 435 WP_076526010.1 SRPBCC domain-containing protein -
GXN75_RS01640 284431..284874 + 444 WP_076526008.1 metalloregulator ArsR/SmtB family transcription factor -
GXN75_RS01645 284825..285374 + 550 Protein_302 GNAT family N-acetyltransferase -
GXN75_RS01650 285459..285671 + 213 WP_172998885.1 hypothetical protein -
GXN75_RS01655 285832..286440 + 609 WP_076526006.1 class I SAM-dependent methyltransferase -
GXN75_RS01660 286464..286997 + 534 WP_076526004.1 DinB family protein -
GXN75_RS01665 287176..287412 + 237 WP_143457159.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GXN75_RS01670 287412..287741 + 330 WP_009710973.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GXN75_RS01675 287786..288130 + 345 WP_076526002.1 metallophosphoesterase family protein -
GXN75_RS01680 288381..288971 + 591 WP_040387597.1 GrpB family protein -
GXN75_RS01685 289150..290469 - 1320 WP_076526000.1 acetamidase/formamidase family protein -
GXN75_RS01690 290797..291516 + 720 WP_076525998.1 MBL fold metallo-hydrolase -
GXN75_RS01695 291531..292123 + 593 Protein_312 WHG domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12203.98 Da        Isoelectric Point: 6.2159

>T148836 WP_009710973.1 NZ_CP048103:287412-287741 [Kroppenstedtia eburnea]
MPTPERGDLVYLNFNPQAGHEQEGERPGIVLSPKAFNHVTGYAVVCPVTRQQKGYPFEVALPDGLVFDGVILTDQVKSLD
WRARRFKIKGRAPDPVIEDCLDLIHTFLS

Download         Length: 330 bp

>T148836 NZ_CP063881:4412087-4412189 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8701.00 Da        Isoelectric Point: 7.3196

>AT148836 WP_143457159.1 NZ_CP048103:287176-287412 [Kroppenstedtia eburnea]
MTTRVQKWGNSLAIRIPKDIADQLAIHQGSELEFIVGSHGITLKPKKQKPTLDDLLAKVTPENRHAEIDFGKEGNELI

Download         Length: 237 bp

>AT148836 NZ_CP063881:c4412196-4412051 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References